NDLI: Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.

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Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.

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Somatostatin-14 and somatostatin-28 induce opposite effects on potassium currents in rat neocortical neurons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, H. L. Reisine, T. Dichter, M. Bogen, C.
Description	Author Affiliation: Wang HL ( Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104.);
Abstract	The prosomatostatin-derived peptides somatostatin-14 (Som-14) and somatostatin-28 (Som-28) are believed to act as neurotransmitters in the central nervous system. To examine possible mechanisms by which these peptides induce their physiological actions in brain, the effects of Som-14 and Som-28 on voltage-dependent K+ currents in rat cerebral cortical neurons in culture were examined by using whole-cell patch-clamp techniques. Som-14 increased a delayed rectifier K+ current (IK) in the cortical neurons, while Som-28 reduced IK in the neurons, both in a concentration-dependent manner. Som-14 and Som-28 could induce opposite changes in IK in the same neurons. Elevating intracellular cAMP in the cortical neurons did not modify the effects of Som-14 or Som-28 on IK, indicating that the peptides can regulate this ionic current through cAMP-independent mechanisms. Pretreatment of the neocortical cells with pertussis toxin, which inactivates inhibitory GTP-binding proteins, abolished both Som-14 and Som-28 modulation of IK, indicating that Som-14 and Som-28 receptors are coupled to IK via GTP-binding proteins. These studies show that Som-14 and Som-28 can induce opposite biological effects, suggesting that Som-14 and Som-28, acting through distinct receptors, may function as different neurotransmitters or neuromodulators.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cerebral Cortex Physiology Neurons Potassium Channels Somatostatin Pharmacology Animals Cells, Cultured Kinetics Membrane Potentials Drug Effects Protein Precursors Somatostatin-28 Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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