NDLI: A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.

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A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.

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Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

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A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Begovich, A. B. Nepom, B. S. Bugawan, T. L. Nepom, G. T. Erlich, H. A. Klitz, W.
Description	Author Affiliation: Begovich AB ( Department of Human Genetics, Cetus Corporation, Emeryville, CA 94608.);
Abstract	Nonradioactive sequence-specific oligonucleotide probes specific for the HLA-DP beta locus have been used in a simple dot-blot format to type samples amplified by the polymerase chain reaction from 44 patients with pauciarticular juvenile rheumatoid arthritis, 32 patients with adult rheumatoid arthritis, and 50 random controls. The sequences of four new DP beta alleles derived from these patients and controls are reported, bringing the total number of alleles identified thus far to 19. The DPB2.1 allele is significantly increased in juvenile rheumatoid arthritis patients over controls; this allele is not increased in patients with adult rheumatoid arthritis. The association of juvenile rheumatoid arthritis with the DPB2.1 allele is independent of linkage with previously defined HLA-D region markers of disease. Analysis of the DPB2.1 sequence shows that it differs from the nonsusceptible DPB4.2 allele by only 1 amino acid at position 69 in the beta 1 domain.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alleles Arthritis, Juvenile Genetics Arthritis, Rheumatoid HLA-DP Antigens Adolescent Amino Acid Sequence Immunology Exons Gene Frequency Genes, MHC Class II Haplotypes Molecular Sequence Data Oligonucleotide Probes Polymerase Chain Reaction Reference Values Sequence Homology, Nucleic Acid Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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