NDLI: Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

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The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo.

Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate immunodeficiency retroviruses.

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Specific photoaffinity labeling of two plasma membrane polypeptides with an azido auxin.

Phytochrome induces changes in the immunodetectable level of a wall peroxidase that precede growth changes in maize seedlings.

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Long-term culture and fine specificity of human cytotoxic T-lymphocyte clones reactive with human immunodeficiency virus type 1.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Fisher, L. Schooley, R. T. Flexner, C. Birch-limberger, K. Young, R. Moss, B. Aldovini, A. Walker, B. D. Paradis, T. J.
Description	Author Affiliation: Walker BD ( Infectious Disease Unit, Massachusetts General Hospital, Boston.);
Abstract	The definition of human immunodeficiency virus type 1 (HIV-1) immunogenic epitopes is central to the rational design of AIDS vaccine strategies. In this study, we have generated seven HIV-1 reverse transcriptase-specific cytotoxic T-lymphocyte (CTL) clones from the peripheral blood of two seropositive subjects. Epitopes recognized by these CTL clones were identified by using target cells infected with recombinant HIV-1-vaccinia virus vectors expressing truncated reverse transcriptase proteins and further defined by using target cells incubated with overlapping 25-amino acid synthetic reverse transcriptase peptides. Five different CTL epitopes were identified, and in each case recognition was restricted by class I human leukocyte antigens (HLA). Clones maintained specific cytolytic function in continuous culture for up to 11 months, requiring only periodic restimulation with a CD3-specific monoclonal antibody. These results indicate that HIV-1-specific, major histocompatibility class I-restricted CTL recognize multiple epitopes of a single viral gene product in conjunction with different host HLA antigens. In addition, they demonstrate that human virus-specific CTL can be grown in long-term culture without the need for reexposure to viral antigen.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	23
Volume Number	86
Language	English
Publisher	National Academy of Sciences
Publisher Date	1989-01-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cytotoxicity, Immunologic HIV-1 Immunology T-Lymphocytes, Cytotoxic Cell Line Cell Transformation, Viral Cells, Cultured Gene Expression Genes, Viral HIV Seropositivity Enzymology Genetics Herpesvirus 4, Human RNA-Directed DNA Polymerase Cytology Vaccinia Virus Viral Structural Proteins Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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