NDLI: HLA-B37 and HLA-A2.1 molecules bind largely nonoverlapping sets of peptides.

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HLA-B37 and HLA-A2.1 molecules bind largely nonoverlapping sets of peptides.

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HLA-B37 and HLA-A2.1 molecules bind largely nonoverlapping sets of peptides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Anderson, R. W. Carreno, B. M. Coligan, J. E. Biddison, W. E.
Description	Author Affiliation: Carreno BM ( Molecular Immunology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892.);
Abstract	T-cell recognition of peptides that are bound and presented by class I major histocompatibility complex molecules is highly specific. At present it is unclear what role class I peptide binding plays relative to T-cell receptor specificity in determination of immune recognition. A previous study from our group demonstrated that the HLA-A2.1 molecule could bind to 25% of the members of a panel of unrelated synthetic peptides as assessed by a functional peptide competition assay. To determine the peptide-binding specificity of another HLA class I molecule, we have examined the capacity of this panel of peptides to compete for the presentation of influenza virus nucleoprotein peptide NP-(335-350) by HLA-B37 to NP-peptide-specific HLA-B37-restricted cytotoxic T-lymphocyte lines. Forty-two percent of peptides tested were capable of inhibiting NP-(335-350) presentation by HLA-B37. Remarkably, none of these HLA-B37-binding peptides belong to the subset that was previously shown to bind to the HLA-A2.1 molecule. Only the NP-(335-350) peptide was capable of binding to both HLA-A2.1 and HLA-B37. These findings demonstrate that the peptide-binding specificities of HLA-B37 and HLA-A2.1 are largely nonoverlapping and suggest that, from the universe of peptides, individual HLA class I molecules can bind to clearly distinct subsets of these peptides.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	HLA-A2 Antigen Immunology HLA-B Antigens T-Lymphocytes Amino Acid Sequence Binding, Competitive Cells, Cultured Genetics HLA-B37 Antigen Kinetics Molecular Sequence Data Peptides Chemical Synthesis Protein Binding Structure-Activity Relationship T-Lymphocytes, Cytotoxic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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