NDLI: Expression of microtubule-associated protein 2 by reactive astrocytes.

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Expression of microtubule-associated protein 2 by reactive astrocytes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Geisert, E. E. Binder, L. I. Johnson, H. G.
Description	Author Affiliation: Geisert EE ( Department of Cell Biology and Anatomy, University of Alabama, Birmingham 35294.);
Abstract	After an injury to the central nervous system, a dramatic change in the astrocytes bordering the wound occurs. The most characteristic feature of this process, termed reactive gliosis, is the upregulation of the intermediate filament protein, glial fibrillary acidic protein. In the present study, we show that reactive astrocytes express high levels of microtubule-associated protein 2 (MAP-2), a protein normally found in the somatodendritic compartment of neurons. When sections of injured brain are double-stained with antibodies directed against MAP-2 and glial fibrillary protein, all of the reactive astrocytes are found to contain MAP-2. The high levels of this protein appear to represent a permanent change in reactive astrocytes. In parallel quantitative studies, an elevated level of MAP-2 in the injured brain is confirmed by an immunoblot analysis of injured and normal white matter. This report demonstrates the direct involvement of a microtubule protein in the process of reactive gliosis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	10
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Astrocytes Metabolism Brain Injuries Microtubule-Associated Proteins Biosynthesis Animals Antibodies, Monoclonal Brain Pathology Epitopes Immunoenzyme Techniques Immunology Molecular Weight Organ Specificity Reference Values Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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