NDLI: Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

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Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

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Identification of type-specific linear epitopes in the glycoproteins gp46 and gp21 of human T-cell leukemia viruses type I and type II using synthetic peptides.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hall, W. W. Jeansson, S. Kaplan, M. H. Vahlne, A. Lycke, J. Horal, P. Rymo, L. Svennerholm, B.
Description	Author Affiliation: Horal P ( Department of Clinical Virology, University of Göteborg, Sweden.);
Abstract	Synthetic peptides of 20-25 amino acids were employed in enzyme-linked immunosorbent assays to identify linear epitopes in the external glycoprotein gp46 and the transmembrane glycoprotein gp21 of human T-cell leukemia/lymphotropic viruses type I (HTLV-I) and II (HTLV-II). Ten linear epitopes were identified in the HTLV-I glycoproteins, seven in gp46 and three in gp21. Three major linear epitopes were identified in the gp46 of HTLV-II. Peptides representing linear epitopes of gp46 were found to be sensitive and specific for the detection of antibody and permit serological identification and differentiation of HTLV-I and HTLV-II infections.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Deltaretrovirus Antigens Immunology Gene Products, Env Human T-lymphotropic Virus 1 Human T-lymphotropic Virus 2 Retroviridae Proteins, Oncogenic Amino Acid Sequence Antibody Specificity Deltaretrovirus Antibodies Epitopes HTLV-I Infections HTLV-II Infections Molecular Sequence Data Species Specificity Env Gene Products, Human Immunodeficiency Virus Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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