NDLI: The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Byrne, J. C. Howley, P. M. Scheffner, M. Münger, K.
Description	Author Affiliation: Scheffner M ( Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, MD 20892.);
Abstract	Human cervical carcinoma cell lines that were either positive or negative for human papillomavirus (HPV) DNA sequences were analyzed for evidence of mutation of the p53 and retinoblastoma genes. Each of five HPV-positive cervical cancer cell lines expressed normal pRB and low levels of wild-type p53 proteins, which are presumed to be altered in function as a consequence of association with HPV E7 and E6 oncoproteins, respectively. In contrast, mutations were identified in the p53 and RB genes expressed in the C-33A and HT-3 cervical cancer cell lines, which lack HPV DNA sequences. Mutations in the p53 genes mapped to codon 273 and codon 245 in the C33-A and HT-3 cell lines, respectively, located in the highly conserved regions of p53, where mutations appear in a variety of human cancers. Mutations in RB occurred at splice junctions, resulting in in-frame deletions, affecting exons 13 and 20 in the HT-3 and C-33A cell lines, respectively. These mutations resulted in aberrant proteins that were not phosphorylated and were unable to complex with the adenovirus E1A oncoprotein. These results support the hypothesis that the inactivation of the normal functions of the tumor-suppressor proteins pRB and p53 are important steps in human cervical carcinogenesis, either by mutation or from complex formation with the HPV E6 and E7 oncoproteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carcinoma Genetics Genes, Retinoblastoma Tumor Suppressor Protein P53 Uterine Cervical Neoplasms Blotting, Western DNA, Neoplasm Genes Immunology Keratinocytes Physiology Molecular Sequence Data Mutation Oligonucleotides Chemistry Papillomaviridae Polymerase Chain Reaction Tumor Cells, Cultured Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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