NDLI: A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1992 Volume: 89 Issue: 24

Year: 1992 Volume: 89 Issue: 23

Year: 1992 Volume: 89 Issue: 22

Year: 1992 Volume: 89 Issue: 21

Year: 1992 Volume: 89 Issue: 20

Year: 1992 Volume: 89 Issue: 19

Year: 1992 Volume: 89 Issue: 18

Year: 1992 Volume: 89 Issue: 17

Year: 1992 Volume: 89 Issue: 16

Year: 1992 Volume: 89 Issue: 15

Year: 1992 Volume: 89 Issue: 14

Year: 1992 Volume: 89 Issue: 13

Year: 1992 Volume: 89 Issue: 12

Year: 1992 Volume: 89 Issue: 11

Year: 1992 Volume: 89 Issue: 10

Year: 1992 Volume: 89 Issue: 9

Year: 1992 Volume: 89 Issue: 8

Year: 1992 Volume: 89 Issue: 7

Year: 1992 Volume: 89 Issue: 6

Year: 1992 Volume: 89 Issue: 5

Year: 1992 Volume: 89 Issue: 4

Calcification in marine molluscs: how costly is it?

Reversible and irreversible intermediates during photoinhibition of photosystem II: stable reduced QA species promote chlorophyll triplet formation.

Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A.

Nonconventional opioid binding sites mediate growth inhibitory effects of methadone on human lung cancer cells.

Synthesis of receptor antagonists of neuropeptide Y.

Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms tumor.

Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice.

Association of the halobacterial 7S RNA to the polysome correlates with expression of the membrane protein bacterioopsin.

A negative retinoic acid response element in the rat oxytocin promoter restricts transcriptional stimulation by heterologous transactivation domains.

Immortalization of primary human smooth muscle cells.

IS5: a mobile enhancer of transcription in Escherichia coli.

A strategy for the generation of conditional mutations by protein destabilization.

Restricted heterogeneity in T-cell antigen receptor V beta gene usage in the lymph nodes and arthritic joints of mice.

The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors.

Viral small nuclear ribonucleoproteins bind a protein implicated in messenger RNA destabilization.

Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes.

Cytotoxic and viral neutralizing antibodies crossreact with streptococcal M protein, enteroviruses, and human cardiac myosin.

A BamHI repeat element is predominantly associated with the degenerating neo-Y chromosome of Drosophila miranda but absent in the Drosophila melanogaster genome.

(125I)iodoazidococaine, a photoaffinity label for the haloperidol-sensitive sigma receptor.

The third gamma subunit of the gamma-aminobutyric acid type A receptor family.

Carbachol-activated calcium entry into HT-29 cells is regulated by both membrane potential and cell volume.

Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.

Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling.

Mutually exclusive exon splicing of the cardiac calcium channel alpha 1 subunit gene generates developmentally regulated isoforms in the rat heart.

Cardiostimulatory and antiarrhythmic activity of tubulin-binding agents.

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases.

T-cell immunity to the joining region of p210BCR-ABL protein.

Global and local genome mapping in Arabidopsis thaliana by using recombinant inbred lines and random amplified polymorphic DNAs.

CD3 zeta dependence of the CD2 pathway of activation in T lymphocytes and natural killer cells.

Neisseria meningitidis encodes an FK506-inhibitable rotamase.

Identification and synthesis of a major conserved antigenic epitope of Trypanosoma cruzi.

Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.

A potentially critical Hpa II site of the X chromosome-linked PGK1 gene is unmethylated prior to the onset of meiosis of human oogenic cells.

The principal neutralization determinant of simian immunodeficiency virus differs from that of human immunodeficiency virus type 1.

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

GP-2/THP gene family encodes self-binding glycosylphosphatidylinositol-anchored proteins in apical secretory compartments of pancreas and kidney.

Consequences of amino acid insertions and/or deletions in transmembrane helix C of bacteriorhodopsin.

Transcriptional activation of the cardiac myosin light chain 2 and atrial natriuretic factor genes by protein kinase C in neonatal rat ventricular myocytes.

Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.

Biosynthesis of phosphatidylinositol-glycan (PI-G)-anchored membrane proteins in cell-free systems: cleavage of the nascent protein and addition of the PI-G moiety depend on the size of the COOH-terminal signal peptide.

Isolation and characterization of the epsilon subspecies of protein kinase C from rat brain.

Mechanism of SOS mutagenesis of UV-irradiated DNA: mostly error-free processing of deaminated cytosine.

Structure of clonal and polyclonal cell arrays in chimeric mouse retina.

The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: isolation and characterization of the gene.

Solid-liquid phase boundaries of lens protein solutions.

Histones H2A/H2B inhibit the interaction of transcription factor IIIA with the Xenopus borealis somatic 5S RNA gene in a nucleosome.

Coexpression of mu and gamma 1 heavy chains can occur by a discontinuous transcription mechanism from the same unrearranged chromosome.

Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain.

Reconstitution of enzymatic activity from fragments of M1 RNA.

Fluorescence lifetime imaging of free and protein-bound NADH.

Protein affinity chromatography with purified yeast DNA polymerase alpha detects proteins that bind to DNA polymerase.

Molecular characterization of two plant flavonol sulfotransferases.

Myb and Ets proteins cooperate in transcriptional activation of the mim-1 promoter.

Two members of a conserved family of nuclear phosphoproteins are involved in pre-mRNA splicing.

Carcinogen-induced frameshift mutagenesis in repetitive sequences.

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120.

Telomeric arrays display high levels of heritable polymorphism among closely related plant varieties.

Over- and under-representation of short oligonucleotides in DNA sequences.

Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.

Role of gender, season, and familiarity in discrimination of conspecific song by zebra finches (Taeniopygia guttata).

Hemispheric differences in avian song discrimination.

Testosterone facilitates some conspecific song discriminations in castrated zebra finches (Taeniopygia guttata).

Mouse model of neurodegeneration: atrophy of basal forebrain cholinergic neurons in trisomy 16 transplants.

Simultaneous visualization of seven different DNA probes by in situ hybridization using combinatorial fluorescence and digital imaging microscopy.

Early molecular events in the induction phase of contact sensitivity.

The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs.

Ontogeny of a biological clock in Drosophila melanogaster.

Antibody-targeted interleukin 2 stimulates T-cell killing of autologous tumor cells.

Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho.

Role of steroid 11 beta-hydroxylase and steroid 18-hydroxylase in the biosynthesis of glucocorticoids and mineralocorticoids in humans.

Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex.

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

Suppression of deregulated c-MYC expression in human colon carcinoma cells by chromosome 5 transfer.

Internal-image anti-idiotype HIV-1gp120 antibody in human immunodeficiency virus 1 (HIV-1)-seropositive individuals with thrombocytopenia.

Phenotypic plasticity in adult sympathetic neurons: changes in neuropeptide expression in organ culture.

A human Id-like helix-loop-helix protein expressed during early development.

Year: 1992 Volume: 89 Issue: 3

Year: 1992 Volume: 89 Issue: 2

Year: 1992 Volume: 89 Issue: 1

On the nature of global classification.

Theory of hydrophobicity: transient cavities in molecular liquids.

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kinoshita, S. Akira, S. Kishimoto, T.
Description	Author Affiliation: Kinoshita S ( Institute for Molecular and Cellular Biology, Osaka University, Japan.);
Abstract	Using a DNA probe from the DNA-binding portion of the NF-IL6 gene and an antibody against the DNA-binding domain of NF-IL6, we isolated a gene homologous to NF-IL6 in the DNA-binding and leucine zipper domains. This intronless gene, termed NF-IL6 beta encodes a 269-amino acid protein with a potential leucine zipper structure, and the gene product can bind to the CCAAT homology as well as the viral enhancer core sequence, as in the cases of NF-IL6 and C/EBP. This gene is expressed at an undetectable or a minor level in normal tissues but is induced by lipopolysaccharide or inflammatory cytokines, as in the case of NF-IL6. NF-IL6 beta easily forms a heterodimer with NF-IL6 in vitro and the heterodimeric complex binds to the same DNA sequence as the respective homodimers. When examined by transient luciferase assays, NF-IL6 beta is consistently a stronger transactivator than NF-IL6. Furthermore, NF-IL6 beta shows a synergistic transcriptional effect with NF-IL6. These data suggest that NF-IL6 beta is an important transcriptional activator in addition to NF-IL6 in regulation of the genes involved in the immune and inflammatory responses.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Genetics Physiology Interleukin-6 Nuclear Proteins Transcription Factors Amino Acid Sequence Blotting, Northern CCAAT-Enhancer-Binding Proteins Cloning, Molecular Gene Expression Gene Expression Regulation In Vitro Techniques Macromolecular Substances Molecular Sequence Data Multigene Family Regulatory Sequences, Nucleic Acid Transcription, Genetic Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in