NDLI: Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

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Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Weissman, I. L. Ikuta, K.
Description	Author Affiliation: Ikuta K ( Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305.);
Abstract	The interaction of the mouse c-kit receptor, designated Kit receptor, and steel factor promotes the proliferation and differentiation of hematopoietic progenitor cells. Monoclonal antibodies against the extracellular portion of the mouse Kit receptor were established. Five percent to 10% of total bone marrow cells expressed the Kit receptor, and half of them lack the expression of lineage markers. The Kit receptor was expressed on 70-80% of Thy-1.1lo Lin-Sca-1+ cells, which express Thy-1.1 antigen at a low level and constitute approximately 0.05% of adult bone marrow and fetal liver; by previous studies, these cells have been shown to be highly enriched for multipotent hematopoietic stem cells (HSCs) and are the only hematopoietic cell subset with this activity. Spleen colony formation and long-term multilineage reconstitution activities were contained in the Kit+ but not in the Kit- subpopulations of Thy-1lo Lin-Sca-1+ cells from adult bone marrow, suggesting that the Kit receptor is expressed on HSCs from the earliest stage-i.e., pluripotent HSCs. The role of steel factor in the development and self-renewal of HSCs was tested with Sl/Sl homozygote fetuses, which lack genes to encode functional steel factor. They were shown to have 30-40% of the number of HSCs on days 13-15 when compared with normal litermates. However, the absolute number of HSCs increased during fetal development in the Sl/Sl mice. The results suggest that the Kit receptor-steel factor interaction may not be essential for the initiation of hematopoiesis and the self-renewal of (at least) fetal HSCs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Hematopoietic Cell Growth Factors Physiology Hematopoietic Stem Cells Proto-Oncogene Proteins Animals Antibodies, Monoclonal Immunology Antigens, Surface Antigens, Thy-1 Bone Marrow Cells Cell Division Flow Cytometry Gene Expression Liver Embryology Mice Proto-Oncogene Proteins C-kit Stem Cell Factor Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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