NDLI: Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho.

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Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho.

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Termination efficiency at rho-dependent terminators depends on kinetic coupling between RNA polymerase and rho.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Jin, D. J. Burgess, R. R. Richardson, J. P. Gross, C. A.
Description	Author Affiliation: Jin DJ ( Department of Bacteriology, University of Wisconsin, Madison 53706.);
Abstract	Rho-dependent terminators constitute one of two major classes of terminators in Escherichia coli. Termination at these sites requires the concerted action of RNA polymerase and rho protein. We present evidence that the efficiency of termination at these sites is governed by kinetic coupling of the rate of transcription of RNA polymerase and the rate of action of rho protein. Termination experiments in vitro indicate that termination efficiency at a rho-dependent terminator is an inverse function of the rate of elongation of RNA polymerase, and each of the mutant phenotypes can be accounted for by the altered rate of elongation of the mutant RNA polymerase. Experiments in vivo show that fast-moving mutant RNA polymerases are termination deficient, while slow-moving mutant RNA polymerases are termination proficient and can suppress the termination deficiency of a slow-acting mutant rho protein. Because of the close coupling of rho action with RNA polymerase, small changes in the elongation rate of RNA polymerase can have very large effects on termination efficiency, providing the cell with a powerful way to modulate termination at rho-dependent terminators.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	89
Language	English
Publisher	National Academy of Sciences
Publisher Date	1992-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Directed RNA Polymerases Metabolism Rho Factor Physiology Terminator Regions, Genetic Transcription, Genetic Genetics Escherichia Coli Kinetics Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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