NDLI: Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide.

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Analysis of stimulation-G protein subunit coupling by using active insulin-like growth factor II receptor peptide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nishimoto, I. Okamoto, T.
Description	Author Affiliation: Okamoto T ( Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.);
Abstract	The peptide Arg2410-Lys2423 (peptide 14) of the human insulin-like growth factor II/mannose 6-phosphate receptor directly activates Gi-2, a GTP-binding protein (G protein), and is responsible for Gi-2 activating function of the receptor. To characterize the basic mechanism of couplings between receptor stimulation and subunits of G proteins, we constructed a system consisting of peptide 14 and alpha and beta gamma subunits of Gi-2 in aqueous solution. Peptide 14 significantly increased the rate of guanosine 5'-[gamma-thio]triphosphate binding to isolated Gi-2 alpha from 0.50 +/- 0.03 (mean +/- SE; n = 3) to 0.75 +/- 0.02 mol per mol of Gi-2 alpha per 3 min (n = 3) at 100 microM. In this system, G beta gamma does dependently potentiated the peptide 14 action on Gi-2 alpha; and G beta gamma-induced potentiation reached saturation at a concentration comparable to that of Gi-2 alpha. An antibody specific for the C-terminal decapeptide of Gi-2 alpha reduce peptide 14-stimulated GDP release from Gi-2 to the basal level. This simplified system indicates that (i) the receptor sequence directly interacts with isolated Gi-2 alpha at its C-terminal region and (ii) G beta gamma potentiates the stimulation-G alpha coupling in a stoichiometrical manner for G alpha.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	88
Language	English
Publisher	National Academy of Sciences
Publisher Date	1991-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	GTP-Binding Proteins Metabolism Insulin-Like Growth Factor II Receptors, Cell Surface Animals In Vitro Techniques Macromolecular Substances Peptides Protein Binding Receptor, IGF Type 2 Chemistry Receptors, Somatomedin Signal Transduction Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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