NDLI: Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

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Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

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Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Furnari, F. B. Pagano, J. S. Adams, M. D.
Description	Author Affiliation: Furnari FB ( Department of Microbiology, University of North Carolina, Chapel Hill 27599.);
Abstract	Northern blot analysis of the Epstein-Barr virus DNA polymerase mRNA identified two discrete sizes of virally encoded polymerase transcripts, 5.08 kb detected in strains P3HR1, Raji, W-91, and FF-41 and 3.7 kb detected solely in the prototype B95-8 strain. 3' S1-nuclease mapping and analysis of cDNA sequence generated by RNA-based PCR demonstrated that the 3.7-kb polymerase mRNA from B95-8 terminates 484 base pairs downstream of the open reading frame in a region of the genome remarkable for its lack of an apparent polyadenylylation signal. Moreover, between the cleavage point and the poly(A) tract of the cDNAs are a series of inserted nucleotides, mostly adenosine and uridine residues of unknown origin. A similar analysis of the 3' terminus of the 5.0-kb mRNA from the other cell lines revealed that polyadenylylation occurs 1.4 kb downstream of the B95-8 terminus. This region is deleted in B95-8, which accounts for the alternate upstream terminus used in B95-8. Like the 3.7-kb terminus, the 5.0-kb terminus lacks a canonical polyadenylylation signal, but contains a rarely used UAUAAA sequence 32 bp upstream of the poly(A) tail. These results indicate that the mRNA encoded by the Epstein-Barr virus DNA polymerase gene is polyadenylylated at two different termini without the use of canonical signals, raising the possibility of involvement of a virus-encoded factor in 3' processing of this message.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Directed DNA Polymerase Genetics Herpesvirus 4, Human Poly A Biosynthesis RNA Processing, Post-Transcriptional RNA, Messenger Transcription, Genetic Animals Cell Line Genome, Viral Enzymology Lymphocytes Cytology Molecular Sequence Data Nucleotides Metabolism Polymerase Chain Reaction Regulatory Sequences, Nucleic Acid Sequence Analysis, DNA Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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