NDLI: The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1993 Volume: 90 Issue: 24

Year: 1993 Volume: 90 Issue: 23

Year: 1993 Volume: 90 Issue: 22

Year: 1993 Volume: 90 Issue: 21

Year: 1993 Volume: 90 Issue: 20

Year: 1993 Volume: 90 Issue: 19

Year: 1993 Volume: 90 Issue: 18

Year: 1993 Volume: 90 Issue: 17

Year: 1993 Volume: 90 Issue: 16

Year: 1993 Volume: 90 Issue: 15

Year: 1993 Volume: 90 Issue: 14

Year: 1993 Volume: 90 Issue: 13

Year: 1993 Volume: 90 Issue: 12

Year: 1993 Volume: 90 Issue: 11

Year: 1993 Volume: 90 Issue: 10

Year: 1993 Volume: 90 Issue: 9

Year: 1993 Volume: 90 Issue: 8

Year: 1993 Volume: 90 Issue: 7

Year: 1993 Volume: 90 Issue: 6

Year: 1993 Volume: 90 Issue: 5

Year: 1993 Volume: 90 Issue: 4

Year: 1993 Volume: 90 Issue: 3

Year: 1993 Volume: 90 Issue: 2

Interpretation of two compact planetary nebulae, IC 4997 and NGC 6572, with aid of theoretical models.

Use of a reporter transgene to generate arabidopsis mutants in ubiquitin-dependent protein degradation.

Stress-induced intrachromosomal recombination in plant somatic cells.

Interaction between a coating-borne peptide of the Brassica pollen grain and stigmatic S (self-incompatibility)-locus-specific glycoproteins.

Double keystone bird in a keystone species complex.

Species selection on variability.

A stochastic interpretation of the Riemann zeta function.

On the span of supersymmetric Young tableaux.

Crystal structure of lignin peroxidase.

Solubilized proteins from carrot (Daucus carota L.) membranes bind calcium channel blockers and form calcium-permeable ion channels.

catELISA: a facile general route to catalytic antibodies.

Evidence for cobinding of self- and allopeptides to human class II major histocompatibility antigen DR1 by energy transfer.

Potent anti-CD5 ricin A chain immunoconjugates from bacterially produced Fab' and F(ab')2.

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes.

Establishment of conditionally immortalized epithelial cell lines from both colon and small intestine of adult H-2Kb-tsA58 transgenic mice.

Identification of a subunit-specific antagonist of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate receptor channels.

The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface.

Roles of the six peptide-binding pockets of the HLA-A2 molecule in allorecognition by human cytotoxic T-cell clones.

Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand.

Acidic C terminus of vaccinia virus DNA-binding protein interacts with ribonucleotide reductase.

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6.

Unconventional processing of the 3' termini of the Epstein-Barr virus DNA polymerase mRNA.

A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus.

Structure of a human rhinovirus complexed with its receptor molecule.

Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line.

Universal mapping probes and the origin of human chromosome 3.

Suppression of tumorigenicity in simian virus 40-transformed 3T3 cells transfected with alpha-actinin cDNA.

Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.

Platelet-derived growth factor (PDGF) in oncogenesis: development of a vascular connective tissue stroma in xenotransplanted human melanoma producing PDGF-BB.

Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

RNA polymerase idling and clearance in gal promoters: use of supercoiled minicircle DNA template made in vivo.

Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study.

Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

Light-driven proton or chloride pumping by halorhodopsin.

Transfer of motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human MET protooncogene.

Bovine papilloma virus (BPV)-encoded E1 protein contains multiple activities required for BPV DNA replication.

An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.

Mouse mammary tumor virus infection accelerates mammary carcinogenesis in Wnt-1 transgenic mice by insertional activation of int-2/Fgf-3 and hst/Fgf-4.

Chloroplast gene sequences and the study of plant evolution.

Identification of a nerve growth factor- and epidermal growth factor-regulated protein kinase that phosphorylates the protooncogene product c-Fos.

A yeast expression system for human galactose-1-phosphate uridylyltransferase.

Rapid, high-level expression of biologically active alpha-trichosanthin in transfected plants by an RNA viral vector.

Genomic structure and chromosomal localization of the human deoxycytidine kinase gene.

Phylogenic and ontogenic expression of hepatocellular bile acid transport.

Protein folding--what's the question?

The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP.

Phospholipid transmembrane domains and lateral diffusion in fibroblasts.

A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae.

Mouse placental macrophages have a decreased ability to present antigen.

Induction of protein-tyrosine-phosphatase activity by interleukin 6 in M1 myeloblastic cells and analysis of possible counteractions by the BCR-ABL oncogene.

Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.

A localized differentiation-inducing-factor sink in the front of the Dictyostelium slug.

In vivo analysis of Chlamydomonas chloroplast petD gene expression using stable transformation of beta-glucuronidase translational fusions.

Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.

Insulin down-regulates expression of the insulin-responsive glucose transporter (GLUT4) gene: effects on transcription and mRNA turnover.

Identification of an RNA binding site for human thymidylate synthase.

Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo.

A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant.

Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA.

A cyclophilin-related protein involved in the function of natural killer cells.

A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.

Erosion kinetics of hydrolytically degradable polymers.

Barium-induced exocytosis is due to internal calcium release and block of calcium efflux.

A possible glycine radical in anaerobic ribonucleotide reductase from Escherichia coli: nucleotide sequence of the cloned nrdD gene.

Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.

Genome mapping by nonrandom anchoring: a discrete theoretical analysis.

The trans-activator tax of human T-cell leukemia virus type 1 (HTLV-1) interacts with cAMP-responsive element (CRE) binding and CRE modulator proteins that bind to the 21-base-pair enhancer of HTLV-1.

Expression of wild-type and mutant bovine pancreatic ribonuclease A in Escherichia coli.

Rhizobium NodB protein involved in nodulation signal synthesis is a chitooligosaccharide deacetylase.

A histidine protein kinase is involved in polar organelle development in Caulobacter crescentus.

Three small nucleolar RNAs of unique nucleotide sequences.

On the nature of the protein folding code.

Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration.

Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences.

Construction of chimeric alleles with altered specificity at the b incompatibility locus of Ustilago maydis.

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

Pleiotrophin transforms NIH 3T3 cells and induces tumors in nude mice.

Protease inhibitors and indoleamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer disease.

Expression of the human neuropeptide tyrosine Y1 receptor.

Acute hypoxia increases ornithine decarboxylase activity and polyamine concentrations in fetal rat brain.

Regulation of cysteine-rich intestinal protein by dexamethasone in the neonatal rat.

Possible role of mammalian secretory group II phospholipase A2 in T-lymphocyte activation: implication in propagation of inflammatory reaction.

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Apolipoprotein J expression at fluid-tissue interfaces: potential role in barrier cytoprotection.

Abnormal activation of H+ conductance in NADPH oxidase-defective neutrophils.

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

Molecular characterization of a kinesin-related antigen of Leishmania chagasi that detects specific antibody in African and American visceral leishmaniasis.

Year: 1993 Volume: 90 Issue: 1

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The ATP-binding component of a prokaryotic traffic ATPase is exposed to the periplasmic (external) surface.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Baichwal, V. Liu, D. Ames, G. F.
Description	Author Affiliation: Baichwal V ( Department of Molecular and Cell Biology, University of California, Berkeley 94720.);
Abstract	The membrane-bound complex of bacterial periplasmic permeases consists of two hydrophobic integral membrane proteins and two copies of a hydrophilic ATP-binding protein. The ATP-binding proteins from all periplasmic permeases display a high level of sequence similarity and are referred to as 'conserved components.' The conserved component from the histidine permease, HisP, has been postulated on the basis of genetic evidence to be accessible at the exterior membrane surface, in contrast to the commonly postulated association with the interior membrane surface as peripheral membrane proteins. We have used proteolysis and biotinylation of membrane vesicles to show that HisP is accessible to these reagents at the external surface and that this orientation depends on the presence of the two hydrophobic components, HisQ and HisM. Several binding-protein-independent hisP mutants are shown to produce HisP proteins that are more susceptible to proteases from the external membrane surface. Since the hydrophilic component is well conserved also in a group of eukaryotic transporters, which together with many prokaryotic systems form the superfamily of traffic ATPases, this insight about its membrane topology has general implications for understanding the molecular mechanism of action of this large superfamily, which includes the cystic fibrosis transmembrane conductance regulator and multidrug-resistance proteins.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	ATP-Binding Cassette Transporters Amino Acid Transport Systems, Basic Bacterial Proteins Cell Compartmentation Cell Membrane Enzymology Membrane Transport Proteins Metabolism Salmonella Typhimurium Adenosine Triphosphatases Adenosine Triphosphate Biological Transport, Active Biotin Drug Effects Cell Polarity Cystic Fibrosis Transmembrane Conductance Regulator Drug Resistance Endopeptidases Pharmacology Histidine Membrane Proteins Surface Properties Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in