NDLI: Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

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Physical cosmology. Introduction to papers presented at a colloquium 'Physical Cosmology,' March 27-28, 1992, National Academy of Sciences, Irvine, CA.

Scientific results from the Cosmic Background Explorer (COBE).

Preliminary results from the third flight of the Millimeter Anisotropy Experiment (MAX).

University of california at Santa Barbara Anisotropy Program: degree scale results from the South Pole 1990-1991.

Challenges to the standard model of Big Bang nucleosynthesis.

Cosmological implications of light element abundances: theory.

Abundances of light elements.

Is the velocity-distance relation for galaxies linear?

The redshift-distance relation.

The Hubble constant.

Tests of the long and short extragalactic distance scales.

Galaxy dynamics and the mass density of the universe.

Derivation of the cosmological density parameter Omega0 from large-scale flows.

Dark matter: theoretical perspectives.

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Causes and effects of the first quasars.

Clusters, superclusters, and large-scale structure: a consistent picture.

Redshift survey with multiple pencil beams at the galactic poles.

Galaxy clustering on large scales.

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An ancient revisits cosmology.

K+-conducting ion channel of the chloroplast inner envelope: functional reconstitution into liposomes.

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance.

The Drosophila Stubble-stubbloid gene encodes an apparent transmembrane serine protease required for epithelial morphogenesis.

Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturations.

Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain.

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens.

Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor.

The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.

Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.

Priming with recombinant influenza virus followed by administration of recombinant vaccinia virus induces CD8+ T-cell-mediated protective immunity against malaria.

Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice.

Genetically controlled food preference: biochemical mechanisms.

GAP-43 augments G protein-coupled receptor transduction in Xenopus laevis oocytes.

Specific labeling and permanent activation of the retinal rod cGMP-activated channel by the photoaffinity analog 8-p-azidophenacylthio-cGMP.

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

Potential role of phospholipase A2 in HL-60 cell differentiation to macrophages induced by protein kinase C activation.

Feedback inhibition of fully unadenylylated glutamine synthetase from Salmonella typhimurium by glycine, alanine, and serine.

Unusual organization of the human T-cell receptor beta-chain gene complex is linked to recombination hotspots.

Molecular and active-site structure of a Bacillus 1,3-1,4-beta-glucanase.

Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene.

Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.

Sites of RNA polymerase III transcription initiation and Ty3 integration at the U6 gene are positioned by the TATA box.

Characterization of glial trkB receptors: differential response to injury in the central and peripheral nervous systems.

Intracellular Ca2+ pool content is linked to control of cell growth.

Maturation stage and proliferation-dependent expression of dUTPase in human T cells.

Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor.

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

Prevention of metastasis by inhibition of the urokinase receptor.

Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy.

Analysis of the mouse protamine 1 promoter in transgenic mice.

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

Physical and functional interaction between WT1 and p53 proteins.

Concordance between isolated cleft palate in mice and alterations within a region including the gene encoding the beta 3 subunit of the type A gamma-aminobutyric acid receptor.

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von Willebrand factor mediates platelet adhesion to virally infected endothelial cells.

Lipid composition and fluidity of the human immunodeficiency virus envelope and host cell plasma membranes.

Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.

"Caged" phenylephrine: development and application to probe the mechanism of alpha-receptor-mediated vasoconstriction.

Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog.

Accessory cholera enterotoxin (Ace), the third toxin of a Vibrio cholerae virulence cassette.

Specific defect in N-acetylglucosamine incorporation in the biosynthesis of the glycosylphosphatidylinositol anchor in cloned cell lines from patients with paroxysmal nocturnal hemoglobinuria.

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Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein.

Solubilized alpha beta Na,K-ATPase remains protomeric during turnover yet shows apparent negative cooperativity toward ATP.

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Differential antagonism of Ras biological activity by catalytic and Src homology domains of Ras GTPase activation protein.

Design superiority of palindromic DNA sites for site-specific recognition of proteins: tests using protein stitchery.

Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium.

Nucleotide-excision repair of DNA in cell-free extracts of the yeast Saccharomyces cerevisiae.

Colocalization of centromeric and replicative functions on autonomously replicating sequences isolated from the yeast Yarrowia lipolytica.

Gene amplification in Rhizobium: identification and in vivo cloning of discrete amplifiable DNA regions (amplicons) from Rhizobium leguminosarum biovar phaseoli.

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.

Echo-planar magnetic resonance imaging studies of frontal cortex activation during word generation in humans.

Nouns and verbs are retrieved with differently distributed neural systems.

p53 gene mutations and protein accumulation in human ovarian cancer.

Axonal sprouting and laminin appearance after destruction of glial sheaths.

Functional heterogeneity of calcium release by inositol trisphosphate in single Purkinje neurones, cultured cerebellar astrocytes, and peripheral tissues.

Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography.

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Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes.

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Chaos and the evolution of cooperation.

Molecular evolution of the Adh1 locus in the genus Zea.

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RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation.

An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase.

Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.

Rapid identification of proteins.

On the regeneration of the actin-myosin power stroke in contracting muscle.

Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck.

Identification of two missense mutations in a dihydrolipoamide dehydrogenase-deficient patient.

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.

Azamacrolides: a family of alkaloids from the pupal defensive secretion of a ladybird beetle (Epilachna varivestis).

Direction of microtubule movement is an intrinsic property of the motor domains of kinesin heavy chain and Drosophila ncd protein.

Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein.

5'-CGA sequence is a strong motif for homo base-paired parallel-stranded DNA duplex as revealed by NMR analysis.

Transfection of the malaria parasite and expression of firefly luciferase.

Control of dorsoventral patterning of somitic derivatives by notochord and floor plate.

Picosecond infrared studies of the dynamics of the photosynthetic reaction center.

Structural changes in the actomyosin cross-bridges associated with force generation.

Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas.

Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.

Isolation and the complete amino acid sequence of lumenal endoplasmic reticulum glucose-6-phosphate dehydrogenase.

Probability of DNA knotting and the effective diameter of the DNA double helix.

A highly polymorphic microsatellite in the class II Eb gene allows tracing of major histocompatibility complex evolution in mouse.

A gamma-aminobutyric acid transporter driven by a proton pump is present in synaptic-like microvesicles of pancreatic beta cells.

Isolation of a proline-rich mycobacterial protein eliciting delayed-type hypersensitivity reactions only in guinea pigs immunized with living mycobacteria.

Prodrug activation via catalytic antibodies.

DNA interstrand cross-links of trans-diamminedichloroplatinum(II) are preferentially formed between guanine and complementary cytosine residues.

A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.

The beta subunit of the mitochondrial processing peptidase from rat liver: cloning and sequencing of a cDNA and comparison with a proposed family of metallopeptidases.

Breaching the conformational integrity of the catalytic triad of the serine protease plasmin: localized disruption of a side chain of His-603 strongly inhibits the amidolytic activity of human plasmin.

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Positional specification of ventricular myosin light chain 2 expression in the primitive murine heart tube.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	O'brien, T. X. Lee, K. J. Chien, K. R.
Description	Author Affiliation: O'Brien TX ( Department of Medicine, Veterans Administration Medical Center, La Jolla, CA.);
Abstract	To study the process of ventricular specification during cardiogenesis, we examined the in situ expression of cardiac ventricular myosin light chain 2 (MLC-2v) mRNA during murine embryogenesis. As assessed by hybridization with a specific MLC-2v riboprobe, mRNA expression can be found in the ventricular region at day 8.0 postcoitum (pc). MLC-2v expression is high in the ventricular portion of the heart tube, with no detectable expression in the atrial or sinus venosus regions. The proximal outflow tract of the heart tube also expresses MLC-2v mRNA at minimally detectable levels at this time but then displays a temporally and spatially distinct pattern with expression well established in the proximal out-flow tract region adjacent to the ventricular segment by days 9-10 pc, eventually reaching levels comparable to the trabeculated ventricular myocardium. By day 11 pc, prior to the completion of septation, expression then becomes restricted to the ventricular region at and below the level of the atrioventricular cushion. Transgenic mice harboring a 250-base-pair MLC-2v promoter fragment fused to a luciferase reporter gene demonstrate reporter gene activity from at least day 9 pc. Ventricular region-restricted expression of the luciferase reporter in the embryonic heart, as assessed by immunofluorescence and direct assay of reporter activity in microdissected atrial and ventricular muscle specimens, was confirmed from at least day 15 pc on. Taken together, this provides evidence for early positional specification of MLC-2v gene expression in the primitive heart tube and indicates regional specification of part of the ventricular muscle gene program can precede ventricular septation during mammalian cardiogenesis. Since the 250-base-pair promoter fragment is active developmentally in transgenic mice, this establishes it as a molecular target for the process of ventricular specification in the developing heart tube.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Heart Embryology Myosins Biosynthesis RNA, Messenger Metabolism Animals Embryonic And Fetal Development Gestational Age Heart Ventricles In Situ Hybridization Luciferases Genetics Mice Mice, Inbred C57BL Mice, Transgenic Myocardium Cytology Promoter Regions, Genetic Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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