NDLI: DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.

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DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.

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DNA target selectivity by the vitamin D3 receptor: mechanism of dimer binding to an asymmetric repeat element.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Freedman, L. P. Asianov, A. Towers, T. L. Luisi, B. F.
Description	Author Affiliation: Towers TL ( Cell Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.);
Abstract	The 1,25-dihydroxyvitamin D3 receptor, like other members of the nuclear receptor superfamily, forms dimers in solution that are probably stabilized by a dyad symmetrical interface formed by the ligand-binding domain. This receptor, however, recognizes DNA targets that are not dyad symmetric but rather are organized as direct repeats of a hexameric sequence with a characteristic 3-bp spacing. Using molecular modeling and site-directed mutagenesis, we have identified regions within the vitamin D3 receptor zinc finger region that confer selectivity for direct repeats with appropriate spacing. Reflecting the organization of the DNA target, these regions, mapping to the tip of the first zinc finger module and the N and C termini of the second finger module, direct asymmetrical protein-protein contacts. A stereochemical model is proposed for these interactions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Metabolism Receptors, Retinoic Acid Receptors, Steroid Repetitive Sequences, Nucleic Acid Transcription Factors Amino Acid Sequence Binding Sites Models, Chemical Molecular Sequence Data Receptors, Calcitriol Receptors, Cell Surface Chemistry Retinoid X Receptors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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