NDLI: Tumor-suppressor genes: news about the interferon connection.

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Tumor-suppressor genes: news about the interferon connection.

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Tumor-suppressor genes: news about the interferon connection.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lengyel, P.
Description	Author Affiliation: Lengyel P ( Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.);
Abstract	The interferons are a family of secreted, multifunctional proteins which are components of the defenses of vertebrates against viral, bacterial, and parasitic infections and certain tumors. They exert their various activities by inducing the synthesis of a large variety of proteins. There are direct and indirect indications that several of these proteins may have tumor-suppressor activities. The interferon-inducible proteins implicated include: (i) a double-stranded RNA-activatable protein kinase that can phosphorylate and thereby inactivate the eukaryotic peptide chain initiation factor eIF-2; (ii) the interferon regulatory factors IRF-1 and IRF-2, which can modulate the expression of the interferons and of some interferon-inducible proteins; and (iii) RNase L, a latent endoribonuclease which can be activated by (2'-5')oligoadenylates, the products of a family of enzymes which are also interferon-inducible. It is note-worthy that some of the proteins encoded by tumor virus oncogenes (e.g., E1A from adenovirus, EBNA-2 from Epstein-Barr virus, and terminal protein from hepatitis B virus) impair the induction of at least some proteins by interferons.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	13
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Genes, Tumor Suppressor Interferons Pharmacology Animals Antigens, Viral Genetics DNA-Binding Proteins Physiology Endoribonucleases Epstein-Barr Virus Nuclear Antigens Interferon Regulatory Factor-1 Phosphoproteins Protein-Serine-Threonine Kinases EIF-2 Kinase Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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