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Protein oxidative damage is associated with life expectancy of houseflies.

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Protein oxidative damage is associated with life expectancy of houseflies.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Agarwal, S. Orr, W. C. Dubey, A. Sohal, R. S.
Description	Author Affiliation: Sohal RS ( Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275.);
Abstract	The objective of this study was to test some of the predictions of the oxidative-stress hypothesis of aging, which postulates that aging is causally associated with the molecular damage inflicted by reactive oxygen species. Protein carbonyl content was used as an index of molecular oxidative modifications. The carbonyl content was found to be associated with the physiological age or life expectancy of flies rather than with their chronological age. Exposure of flies to sublethal hyperoxia (100% oxygen) irreversibly enhanced the carbonyl content of the flies and decreased their rate of oxygen consumption. Results of this study indicate that protein carbonyl content may be a biomarker of aging and support the general concept that oxidative stress may be a causal factor in the aging process.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Houseflies Physiology Life Expectancy Oxygen Metabolism Proteins Chemistry Animals Catalase Glutathione Oxidation-Reduction Toxicity Oxygen Consumption Physical Exertion Superoxide Dismutase Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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