NDLI: Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

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Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Roder, J. C. Rossant, J. Nagy, R. Nagy, A. Abramow-newerly, W.
Description	Author Affiliation: Nagy A ( Division of Molecular and Developmental Biology, Samuel Lumenfeld Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.);
Abstract	Several newly generated mouse embryonic stem (ES) cell lines were tested for their ability to produce completely ES cell-derived mice at early passage numbers by ES cell <==> tetraploid embryo aggregation. One line, designated R1, produced live offspring which were completely ES cell-derived as judged by isoenzyme analysis and coat color. These cell culture-derived animals were normal, viable, and fertile. However, prolonged in vitro culture negatively affected this initial totipotency of R1, and after passage 14, ES cell-derived newborns died at birth. However, one of the five subclones (R1-S3) derived from single cells at passage 12 retained the original totipotency and gave rise to viable, completely ES cell-derived animals. The total in vitro culture time of the sublines at the time of testing was equivalent to passage 24 of the original line. Fully potent early passage R1 cells and the R1-S3 subclone should be very useful not only for ES cell-based genetic manipulations but also in defining optimal in vitro culture conditions for retaining the initial totipotency of ES cells.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Blastocyst Physiology Embryonic And Fetal Development Stem Cells Animals Cell Aggregation Cell Line Chimera Embryo Implantation Fetal Death Fetal Resorption Genetic Markers Glucose-6-Phosphate Isomerase Genetics Karyotyping Mice Mice, Mutant Strains Polyploidy Pregnancy Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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