NDLI: Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint.

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Positional cloning of the hereditary renal carcinoma 3;8 chromosome translocation breakpoint.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wilke, C. M. Glover, T. W. Boldog, F. L. Chandrasekharappa, S. C. Brown, R. S. Nilsson, A. S. Li, F. P. Gemmill, R. M. Drabkin, H. A.
Description	Author Affiliation: Boldog FL ( University of Colorado Cancer Center, Division of Medical Oncology, Denver 80262.);
Abstract	The chromosome (p14.2;q24.1) translocation t(3;8) has been associated with hereditary renal cancer in one family. Based on cytogenetic analyses and loss-of-heterozygosity experiments, the 3p14 region has been independently implicated as harboring a tumor suppressor gene critical to kidney and lung cancer development. The 3p14.2 region also contains FRA3B, the most sensitive fragile site induced by aphidicolin. A chromosome 3 probe, R7K145, derived from a radiation-reduced hybrid was positioned between the t(3;8) breakpoint and an aphidicolin-induced 3p14 breakpoint. A yeast artificial chromosome (YAC) contig containing R7K145 was developed that crossed the aphidicolin-induced breakpoint on its telomeric side. A subsequent chromosome walk identified a YAC that crossed the 3;8 translocation breakpoint. A lambda sublibrary allowed isolation of clones spanning the rearrangement. Unique and evolutionarily conserved DNA sequences were used to screen a kidney cDNA library. We have identified a gene, referred to as HRCA1 (hereditary renal cancer associated 1), that maps immediately adjacent to the breakpoint. On the basis of its chromosomal position, HRCA1 may be a candidate tumor suppressor gene.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 3 Chromosomes, Human, Pair 8 Translocation, Genetic Urinary Bladder Neoplasms Genetics Animals Blotting, Northern Cell Line Chromosome Aberrations Chromosome Mapping Clone Cells Cloning, Molecular DNA Isolation & Purification DNA Probes Gene Library Hybrid Cells Kidney RNA Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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