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A conserved helix motif complements the protein kinase core.

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A conserved helix motif complements the protein kinase core.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Veron, M. Tsigelny, I. Taylor, S. S. Ten Eyck, L. F. Radzio-andzelm, E.
Description	Author Affiliation: Veron M ( Unité de Biochimie Cellulaire, Centre National de la Recherche Scientifique: URA1129, Institut Pasteur, France.);
Abstract	Residues 40-300 of the mammalian catalytic (C) subunit of cAMP-dependent protein kinase define a conserved bilobal catalytic core shared by all eukaryotic protein kinases. Contiguous to the core is an extended amphipathic alpha-helix (A helix). Trp30, a prominent feature of this helix, fills a deep hydrophobic pocket between the two lobes on the surface opposite to the active site. The C subunit in Dictyostelium discoideum shows sequence conservation of residues 40-350 with the mouse enzyme but contains an N-terminal extension of 332 residues. A sequence corresponding to the A helix contiguous to the core is absent. However, we have now identified a remote A-helix motif (residues 77-98). When the core of the Dictyostelium C subunit was modeled, based on the mouse C subunit, complementarity between this putative A helix and the surface of the core was found to be conserved. Analysis of other protein kinases reveals that the A-helix motif is not restricted to cAMP-dependent protein kinase. In the Src-related family of protein kinases, for example, an A helix is very likely contiguous to the core, thus serving as a linker between the conserved catalytic core and the Src homology 2 domain. We predict that an A-helix motif complementary to the core will be a conserved feature of most eukaryotic protein kinases.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	22
Volume Number	90
Language	English
Publisher	National Academy of Sciences
Publisher Date	1993-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cyclic AMP-Dependent Protein Kinases Chemistry Dictyostelium Enzymology Amino Acid Sequence Animals Casein Kinases Mice Models, Molecular Molecular Sequence Data Protein Kinases Protein Structure, Secondary Protein Structure, Tertiary Protein-Tyrosine Kinases Proto-Oncogene Proteins Pp60(c-src) Sequence Alignment Sequence Homology, Amino Acid Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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