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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Steward, O. Banker, G. Kleiman, R. |
| Description | Author Affiliation: Kleiman R ( Department of Neuroscience, University of Virginia Health Sciences Center, Charlottesville 22908.); |
| Abstract | This study evaluates whether protein synthesis plays a role in targeting RNA molecules to different subcellular domains within neurons. Transport of newly synthesized RNA (labeled with [3H]uridine) was examined in the presence of the protein synthesis inhibitors puromycin and cycloheximide. In situ hybridization was used to determine whether inhibition of protein synthesis altered the subcellular distribution of mRNAs. Transport of recently synthesized RNA was not disrupted after prolonged exposure to either inhibitor. However, inhibition of protein synthesis caused several mRNAs that are normally confined to the cell body to appear in dendrites. The distribution of mRNAs that are normally present in dendrites was unaffected. These findings suggest that protein synthesis is not required to translocate RNA into the dendrites but may play a role in restricting particular mRNAs to the neuronal cell body. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Nerve Tissue Proteins Genetics Neurons Metabolism Protein Synthesis Inhibitors Pharmacology RNA, Messenger Actins Biological Transport Drug Effects Cell Compartmentation Cells, Cultured GAP-43 Protein Hippocampus In Vitro Techniques Membrane Glycoproteins Microtubule-Associated Proteins Tubulin Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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