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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Leung, M. K. Stefano, G. B. Digenis, A. Spector, S. Scharrer, B. Bilfinger, T. V. Makman, M. H. Abumrad, N. N. |
| Description | Author Affiliation: Stefano GB ( Multidisciplinary Center for the Study of Aging, Old Westbury Neuroscience Research Institute, State University of New York 11568.); |
| Abstract | The presence of morphine-like and codeine-like substances was demonstrated in the pedal ganglia, hemolymph, and mantle tissues of the mollusc Mytilus edulis. The pharmacological activities of the endogenous morphine-like material resemble those of authentic morphine. Both substances were found to counteract, in a dose-dependent manner, the stimulatory effect of tumor necrosis factor alpha or interleukin 1 alpha on human monocytes and Mytilus immunocytes, when added simultaneously to the incubation medium. The immunosuppressive effect of this opiate material expresses itself in a lowering of chemotactic activity, cellular velocity, and adherence. Codeine mimics the activity of authentic morphine, but only at much higher concentrations. Specific high-affinity receptor sites (mu 3) for morphine have been identified on human monocytes and Mytilus immunocytes. In Mytilus recovering from experimentally induced stress, the return of 'altered' immunocytes to a more inactive state appears to be due to a significant rise in the content of morphine-like material in the pedal ganglia and hemolymph at this time. Thus, morphine may have a role in calming or terminating the state of immune alertness. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 23 |
| Volume Number | 90 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1993-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bivalvia Physiology Monocytes Narcotics Pharmacology Receptors, Opioid Animals Binding, Competitive Chemotaxis, Leukocyte Drug Effects Ganglia, Invertebrate Chemistry Hemolymph In Vitro Techniques Ligands Morphine Stress, Physiological Physiopathology Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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