NDLI: Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

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Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Passador, L. Pearson, J. P. Eberhard, A. Iglewski, B. H. Gray, K. M. Tucker, K. D. Greenberg, E. P.
Description	Author Affiliation: Pearson JP ( Department of Microbiology, University of Iowa, Iowa City 52242.);
Abstract	In Pseudomonas aeruginosa the LasR protein is required for activation of lasB and several other virulence genes. A diffusible signal molecule, the P. aeruginosa autoinducer (PAI), produced by the bacterial cell and released into the growth medium, is required for activity of LasR. By cloning a lasB::lacZ fusion and a lasR gene under control of the lac promoter in Escherichia coli, we have developed a quantitative bioassay for PAI. We have used this assay to follow the purification of PAI from cell-free culture supernatant fluids in which P. aeruginosa or E. coli containing the P. aeruginosa gene required for autoinducer synthesis, lasI, had been grown. Chemical analyses indicated the purified material was 3-oxo-N-(tetrahydro-2-oxo-3-furanyl)dodecanamide. To confirm this assignment, the compound was synthesized and the synthetic compound was shown to have chemical and biological properties identical to those of PAI purified from culture supernatant fluids. The elucidation of the PAI structure suggests therapeutic approaches toward control of P. aeruginosa infections.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation, Bacterial Genes, Bacterial Homoserine Analogs & Derivatives Lactones Chemistry Pseudomonas Aeruginosa Bacterial Proteins Physiology Mass Spectrometry Genetics Pathogenicity RNA, Messenger Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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