NDLI: Synapsin IIa accelerates functional development of neuromuscular synapses.

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Synapsin IIa accelerates functional development of neuromuscular synapses.

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Synapsin IIa accelerates functional development of neuromuscular synapses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Greengard, P. Schaeffer, E. Alder, J. Poo, M. M.
Description	Author Affiliation: Schaeffer E ( Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, NY 10021.);
Abstract	We have investigated the possible involvement of the synaptic vesicle protein synapsin IIa in synapse development. Synapsin IIa was introduced into Xenopus embryonic spinal neurons by early blastomere injection, and nerve-muscle cultures were prepared. Synaptic currents were measured by comparing synapses in which the presynaptic neuron either contained [syn IIa (+)] or lacked (control) exogenous synapsin IIa. Syn IIa (+) synapses had a 3.6-fold increase in the frequency and a 2.1-fold increase in the amplitude of spontaneous synaptic currents, compared to controls, after 2 days in culture. Synapsin IIa also increased the amplitude of evoked synaptic currents by 2.3-fold in 2-day cultures. The evoked synaptic current amplitudes of syn IIa (+) synapses had a lower coefficient of variation indicating a more stable evoked response. These enhanced synaptic activities were independent of the presence or absence of the protein in the postsynaptic muscle cell. The findings indicate a role for synapsin IIa in synapse maturation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neuromuscular Junction Physiology Synapses Synapsins Acetylcholine Animals Cell Differentiation Cells, Cultured Electrophysiology In Vitro Techniques Cytology Recombinant Proteins Pharmacology Synaptic Transmission Xenopus Laevis Embryology Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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