NDLI: Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

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Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

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Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miyashita, H. Watanabe, T. Yonekura, H. Suzuki, Y. Sugiyama, K. Unno, M. Yonemura, Y. Moriizumi, S. Kondo, H. Tanaka, O.
Description	Author Affiliation: Watanabe T ( Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan.);
Abstract	We previously isolated from a rat regenerating islet cDNA library a gene named Reg, which is expressed in regenerating islets but is not expressed in normal islets. Here we examined the effect of rat Reg protein on pancreatic beta-cell replication using both 90% depancreatized rats and isolated islets. The depancreatized rats that received i.p. administration of recombinant rat Reg protein (1 mg/kg per day) for 2 months showed amelioration of the surgical diabetes, as evidenced by a significant decrease in blood glucose with an increased beta-cell mass in the residual pancreas. In isolated rat islets, Reg protein (18-180 nM: 0.3-3 micrograms/ml) significantly increased [3H]thymidine incorporation into the nuclei of beta cells. These results indicate that Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium-Binding Proteins Pharmacology Diabetes Mellitus, Experimental Drug Therapy Islets Of Langerhans Physiology Nerve Tissue Proteins Animals Cell Division Lithostathine Pancreatectomy Rats, Wistar Recombinant Proteins Regeneration Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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