NDLI: The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1994 Volume: 91 Issue: 26

Year: 1994 Volume: 91 Issue: 26 Suppl

Year: 1994 Volume: 91 Issue: 25

Year: 1994 Volume: 91 Issue: 24

Year: 1994 Volume: 91 Issue: 23

Year: 1994 Volume: 91 Issue: 22

Year: 1994 Volume: 91 Issue: 21

Year: 1994 Volume: 91 Issue: 20

Year: 1994 Volume: 91 Issue: 19

Year: 1994 Volume: 91 Issue: 18

Year: 1994 Volume: 91 Issue: 17

Year: 1994 Volume: 91 Issue: 16

Year: 1994 Volume: 91 Issue: 15

Year: 1994 Volume: 91 Issue: 14

Year: 1994 Volume: 91 Issue: 13

Year: 1994 Volume: 91 Issue: 12

Year: 1994 Volume: 91 Issue: 11

Year: 1994 Volume: 91 Issue: 10

Year: 1994 Volume: 91 Issue: 9

Cyclic nucleotide-gated channels: an expanding new family of ion channels.

Evolutionary origins of ion channels.

Potentiation of osteoclast bone-resorption activity by inhibition of nitric oxide synthase.

Redox regulation of signal transduction: tyrosine phosphorylation and calcium influx.

RNA cleavage and chain elongation by Escherichia coli DNA-dependent RNA polymerase in a binary enzyme.RNA complex.

Structure of the binding site for nonnucleoside inhibitors of the reverse transcriptase of human immunodeficiency virus type 1.

The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B.

Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src.

Heterogeneous activation thresholds to cytokines in genetically distinct endothelial cells: evidence for diverse transcriptional responses.

Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells.

Thalidomide is an inhibitor of angiogenesis.

Cell biological mechanisms of multidrug resistance in tumors.

Compartmentalization of two forms of acetyl-CoA carboxylase in plants and the origin of their tolerance toward herbicides.

Molecular analysis of antigen-independent adhesion forces between T and B lymphocytes.

Molecular basis of splotch and Waardenburg Pax-3 mutations.

Roles of pilin and PilC in adhesion of Neisseria meningitidis to human epithelial and endothelial cells.

CD4 is a critical component of the receptor for human herpesvirus 7: interference with human immunodeficiency virus.

Cyclophilin B trafficking through the secretory pathway is altered by binding of cyclosporin A.

Purification and physiological evaluation of a guanylate cyclase activating protein from retinal rods.

Negative selection of CD4+ CD8+ thymocytes by T-cell receptor peptide antagonists.

The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.

Scientific conduct.

T-cell antigens in cancer.

Inactivation of gene expression in plants as a consequence of specific sequence duplication.

Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart.

An Escherichia coli homologue of eukaryotic potassium channel proteins.

Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.

Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding.

Binding of histones H1 and H5 and their globular domains to four-way junction DNA.

Magnetic resonance microscopy of mouse embryos.

Bromophenacyl bromide binding to the actin-bundling protein l-plastin inhibits inositol trisphosphate-independent increase in Ca2+ in human neutrophils.

Insertional mutagenesis of Drosophila heterochromatin with single P elements.

Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation.

Dominant dystrophic epidermolysis bullosa: identification of a Gly-->Ser substitution in the triple-helical domain of type VII collagen.

Fine structure analysis of the WT1 gene in sporadic Wilms tumors.

Inhibition of cytochromes P4501A by nitric oxide.

Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells.

First epidermal growth factor-like domain of human blood coagulation factor IX is required for its activation by factor VIIa/tissue factor but not by factor XIa.

'...the tyranny of the lattice...'.

Tax protein of human T-cell leukemia virus type I binds to the ankyrin motifs of inhibitory factor kappa B and induces nuclear translocation of transcription factor NF-kappa B proteins for transcriptional activation.

Pancreatic beta-cell replication and amelioration of surgical diabetes by Reg protein.

A recombinant bisphosphoglycerate mutase variant with acid phosphatase homology degrades 2,3-diphosphoglycerate.

p53 and E2F-1 cooperate to mediate apoptosis.

Rodent BC1 RNA gene as a master gene for ID element amplification.

Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice.

The human homologue of the retroviral oncogene qin maps to chromosome 14q13.

Synthetic peptide ligands of the antigen binding receptor induce programmed cell death in a human B-cell lymphoma.

An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.

Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase.

Recombination between defective tombusvirus RNAs generates functional hybrid genomes.

Id-1 as a possible transcriptional mediator of muscle disuse atrophy.

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

A Rev-inducible mutant gag gene stably transferred into T lymphocytes: an approach to gene therapy against human immunodeficiency virus type 1 infection.

Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insulin-dependent diabetes mellitus.

Selective 5-HT1D alpha serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development.

A faster-acting and more potent form of tissue plasminogen activator.

De novo design and structural characterization of an alpha-helical hairpin peptide: a model system for the study of protein folding intermediates.

Nitric oxide reacts with intracellular glutathione and activates the hexose monophosphate shunt in human neutrophils: evidence for S-nitrosoglutathione as a bioactive intermediary.

Evidence that an amoeba acquired a chloroplast by retaining part of an engulfed eukaryotic alga.

Mast cells with gonadotropin-releasing hormone-like immunoreactivity in the brain of doves.

Targeted disruption of Bcl-2 alpha beta in mice: occurrence of gray hair, polycystic kidney disease, and lymphocytopenia.

Rapid cell variation can determine the establishment of a persistent viral infection.

The nature of the autoimmune antibody repertoire in human immunodeficiency virus type 1 infection.

Parasite virulence and disease patterns in Plasmodium falciparum malaria.

Mutants of Escherichia coli K-12 that are resistant to a selenium analog of lipoic acid identify unknown genes in lipoate metabolism.

UV photoelectron and ab initio quantum mechanical characterization of valence electrons in Na(+)-water-2'-deoxyguanosine 5'-phosphate clusters: electronic influences on DNA alkylation by methylating and ethylating carcinogens.

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

Discrimination of odortypes determined by the major histocompatibility complex among outbred mice.

Mast cells synthesize, store, and release nerve growth factor.

Cloning mammalian genes by expression selection of genetic suppressor elements: association of kinesin with drug resistance and cell immortalization.

N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations.

Activation of cyclin A-dependent protein kinases during apoptosis.

Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes.

Cytotoxic T lymphocytes inhibit hepatitis B virus gene expression by a noncytolytic mechanism in transgenic mice.

Properties of angiotensin II receptors in glial cells from the adult corpus callosum.

Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor.

Na(+)-I- symport activity is present in membrane vesicles from thyrotropin-deprived non-I(-)-transporting cultured thyroid cells.

A cellular factor is required for transcription of vaccinia viral intermediate-stage genes.

Pervasive CpG suppression in animal mitochondrial genomes.

Synergistic effects of bombesin and epidermal growth factor on cancers.

In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden strain cross-reactivity.

Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers.

Amplification of trpEG: adaptation of Buchnera aphidicola to an endosymbiotic association with aphids.

Expression of TrkA confers neuron-like responsiveness to nerve growth factor on an immortalized hypothalamic cell line.

Diffusivity of myoglobin in intact skeletal muscle cells.

PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro.

Replication initiator protein RepE of mini-F plasmid: functional differentiation between monomers (initiator) and dimers (autogenous repressor).

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

Sigma factors, asymmetry, and the determination of cell fate in Bacillus subtilis.

The sequence, and its evolutionary implications, of a Thermococcus celer protein associated with transcription.

Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid.

Cellular latency in human immunodeficiency virus-infected individuals with high CD4 levels can be detected by the presence of promoter-proximal transcripts.

Redox modulation of the expression of bacterial genes encoding cysteine-rich proteins in plant protoplasts.

NMR observation of substrate in the binding site of an active sugar-H+ symport protein in native membranes.

Synapsin IIa accelerates functional development of neuromuscular synapses.

An altered-specificity mutation in a human POU domain demonstrates functional analogy between the POU-specific subdomain and phage lambda repressor.

Peptide nucleic acid.DNA strand displacement loops as artificial transcription promoters.

Growth factor-mediated induction of the delayed early gene T1 depends on a 12-O-tetradecanoylphorbol 13-acetate-responsive element located 3.6 kb upstream of the transcription initiation site.

Transcriptional activation by CTF proteins is mediated by a bipartite low-proline domain.

Organization of pioneer retinal axons within the optic tract of the rhesus monkey.

Timely immunization subverts the development of peripheral nonresponsiveness and suppresses tumor development in simian virus 40 tumor antigen-transgenic mice.

Metaphase and anaphase in the artificially induced monopolar spindle.

Yeast RAD3 protein binds directly to both SSL2 and SSL1 proteins: implications for the structure and function of transcription/repair factor b.

Naturally processed heterodimeric disulfide-linked insulin peptides bind to major histocompatibility class II molecules on thymic epithelial cells.

A model of dendritic spine Ca2+ concentration exploring possible bases for a sliding synaptic modification threshold.

Left hemisphere dominance for processing vocalizations in adult, but not infant, rhesus monkeys: field experiments.

Expression of trk in MAH cells lacking the p75 low-affinity nerve growth factor receptor is sufficient to permit nerve growth factor-induced differentiation to postmitotic neurons.

Polyamines regulate the expression of ornithine decarboxylase antizyme in vitro by inducing ribosomal frame-shifting.

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

A permutational approach toward protein-DNA recognition.

Erythropoietin receptor mRNA expression in human endothelial cells.

Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53.

Canine X chromosome-linked hereditary nephritis: a genetic model for human X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV.

Two point mutations within the adducin genes are involved in blood pressure variation.

Consistent intergenic splicing and production of multiple transcripts between AML1 at 21q22 and unrelated genes at 3q26 in (3;21)(q26;q22) translocations.

Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.

Inhibition of inward K+ channels and stomatal response by abscisic acid: an intracellular locus of phytohormone action.

Structure and function in rhodopsin: the role of asparagine-linked glycosylation.

Structure and function in rhodopsin: replacement by alanine of cysteine residues 110 and 187, components of a conserved disulfide bond in rhodopsin, affects the light-activated metarhodopsin II state.

The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase.

Avian erythroblastosis virus E26: only one (myb) of two cell-derived coding regions is necessary for oncogenicity.

Underlying order in protein sequence organization.

Correction of the DNA repair defect in xeroderma pigmentosum group E by injection of a DNA damage-binding protein.

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

Apoptosis mediates and thymidine prevents erythroblast destruction in folate deficiency anemia.

Dual inhibition of angiotensin-converting enzyme and neutral endopeptidase by the orally active inhibitor mixanpril: a potential therapeutic approach in hypertension.

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

Gene transfer in vivo: sustained expression and regulation of genes introduced into the liver by receptor-targeted uptake.

L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.

Year: 1994 Volume: 91 Issue: 8

Year: 1994 Volume: 91 Issue: 7

Year: 1994 Volume: 91 Issue: 6

Year: 1994 Volume: 91 Issue: 5

Year: 1994 Volume: 91 Issue: 4

Year: 1994 Volume: 91 Issue: 3

Year: 1994 Volume: 91 Issue: 2

Year: 1994 Volume: 91 Issue: 1

Impact melting of frozen oceans on the early Earth: Implications for the origin of life

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The des(1-6)antennapedia homeodomain: comparison of the NMR solution structure and the DNA-binding affinity with the intact Antennapedia homeodomain.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wüthrich, K. Qian, Y. Q. Resendez-perez, D. Gehring, W. J.
Description	Author Affiliation: Qian YQ ( Institut für Molekularbiologie und Biophysik, Eidgenössiche Technische Hochschule-Hönggerberg, Zürich, Switzerland.);
Abstract	The nuclear magnetic resonance (NMR) solution structure of an N-terminally truncated mutant Antennapedia homeodomain, des(1-6)Antp(C39S), has been determined from 935 nuclear Overhauser effect upper distance constraints and 148 dihedral angle constraints by using the programs DIANA and OPAL. Twenty conformers representing the solution structure of des(1-6)Antp(C39S) have an average root-mean-square distance relative to the mean coordinates of 0.56 A for the backbone atoms of residues 8-59. Comparison with the intact Antp(C39S) homeodomain shows that the two proteins have identical molecular architectures. The removal of the N-terminal residues 1-6, which are flexibly disordered in the intact homeodomain, causes only strictly localized structure variations and does not noticeably affect the adjoining helix I from residues 10-21. The DNA-binding constant of des(1-6)Antp(C39S) is approximately 10-fold reduced relative to the intact Antp(C39S) homeodomain, which can now be attributed to the absence of the previously reported contacts of the N-terminal polypeptide segment of the intact Antp(C39S) homeodomain with the minor groove of the DNA duplex.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	9
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA-Binding Proteins Metabolism Homeodomain Proteins Nuclear Proteins Transcription Factors Amino Acid Sequence Animals Antennapedia Homeodomain Protein DNA Primers Chemistry Ultrastructure Drosophila Proteins Drosophila Melanogaster Genes, Homeobox Magnetic Resonance Spectroscopy Molecular Sequence Data Protein Structure, Tertiary Recombinant Proteins Structure-Activity Relationship Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in