NDLI: Id proteins control growth induction in mammalian cells.

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Id proteins control growth induction in mammalian cells.

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Id proteins control growth induction in mammalian cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Philipson, L. Barone, M. V. Peverali, F. A. Pepperkok, R.
Description	Author Affiliation: Barone MV ( European Molecular Biology Laboratory, Heidelberg, Germany.);
Abstract	Id1, Id2, and Id3 (HLH462) dimerize with members of the basic helix-loop-helix protein family, but due to the absence of the basic region, the resulting heterodimers cannot bind DNA. Therefore Id-type proteins negatively regulate DNA binding of the basic helix-loop-helix proteins. Here we report that Id1, Id2, and Id3 are induced shortly after serum stimulation in arrested NIH 3T3. Antisense oligonucleotides against the Id mRNAs delay the reentry of arrested cells into the cell cycle elicited by stimulation with serum or growth factors. Antisense oligonucleotides against all three Id mRNAs are more effective than individual ones. Combined, these results indicate that Id proteins are involved in the control of growth induction.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Division Physiology DNA-Binding Proteins Helix-Loop-Helix Motifs Repressor Proteins Transcription Factors 3T3 Cells Animals Blotting, Northern DNA Growth Substances Inhibitor Of Differentiation Protein 1 Mice Molecular Sequence Data Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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