NDLI: Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

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Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

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Membrane-derived second messenger regulates x-ray-mediated tumor necrosis factor alpha gene induction.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hallahan, D. E. Virudachalam, S. Kufe, D. W. Weichselbaum, R. R. Kuchibhotla, J.
Description	Author Affiliation: Hallahan DE ( Department of Radiation and Cellular Oncology, University of Chicago, IL 60637.);
Abstract	Cells adapt to adverse environmental conditions through a wide range of responses that are conserved throughout evolution. Physical agents such as ionizing radiation are known to initiate a stress response that is triggered by the recognition of DNA damage. We have identified a signaling pathway involving the activation of phospholipase A2 and protein kinase C in human cells that confers x-ray induction of the tumor necrosis factor alpha gene. Treatment of human cells with ionizing radiation or H2O2 was associated with the production of arachidonic acid. Inhibition of phospholipase A2 abolished radiation-mediated arachidonate production as well as the subsequent activation of protein kinase C and tumor necrosis factor alpha gene expression. These findings demonstrate that ionizing radiation-mediated gene expression in human cells is regulated in part by extranuclear signal transduction. One practical application of phospholipase A2 inhibitors is to ameliorate the adverse effects of radiotherapy associated with tumor necrosis factor alpha production.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation Radiation Effects Second Messenger Systems Tumor Necrosis Factor-alpha Genetics Amino Acid Sequence Arachidonic Acids Biosynthesis Cell Line Cell Membrane Metabolism Enzyme Activation Molecular Sequence Data Phospholipases A Antagonists & Inhibitors Phospholipases A2 Protein Kinase C Transcriptional Activation Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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