NDLI: High-resolution laser desorption mass spectrometry of peptides and small proteins.

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TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

Functional unit size of the charybdotoxin receptor in smooth muscle.

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High-resolution laser desorption mass spectrometry of peptides and small proteins.

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Impact melting of frozen oceans on the early Earth: Implications for the origin of life

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High-resolution laser desorption mass spectrometry of peptides and small proteins.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hunter, R. L. Mciver, R. T. Li, Y.
Description	Author Affiliation: McIver RT ( Department of Chemistry, University of California, Irvine 92717.);
Abstract	Matrix-assisted laser desorption/ionization (MALDI) has been used with an external ion source Fourier-transform mass spectrometer to obtain the highest mass resolution ever, to our knowledge, demonstrated for laser-produced ions (m/delta m = 1,100,000 for [Arg8]vasopressin, 228,000 for melittin, and 90,000 for bovine insulin). The peaks in the isotope cluster for bovine insulin are fully resolved, and the mass measurement accuracy is an order of magnitude better than can be achieved with time-of-flight mass spectrometry. With the method described here, analyte is applied to a sample probe and mixed with a solution containing a matrix material (2,5-dihydroxybenzoic acid) that strongly absorbs ultraviolet light. Upon irradiation with a pulse from an excimer laser (353 nm, 2 mJ), a large number of intact protonated molecular ions are produced. The ions are focused by a 117-cm-long quadrupole ion guide and injected into an ion cyclotron resonance analyzer cell located inside the bore of a 6.5-T superconducting magnet. A pulse of argon buffer gas cools the ions prior to detection. One of the principal advantages of an external ion source Fourier-transform mass spectrometer is that the ion formation and ion detection processes are separated and can be independently optimized.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	11
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-06-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Mass Spectrometry Peptides Chemistry Proteins Animals Fourier Analysis Insulin Ions Lasers Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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