NDLI: Cyclic Ca2+ changes in intracellular stores of gonadotropes during gonadotropin-releasing hormone-stimulated Ca2+ oscillations.

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Cyclic Ca2+ changes in intracellular stores of gonadotropes during gonadotropin-releasing hormone-stimulated Ca2+ oscillations.

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Cyclic Ca2+ changes in intracellular stores of gonadotropes during gonadotropin-releasing hormone-stimulated Ca2+ oscillations.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hille, B. Tse, F. W. Tse, A.
Description	Author Affiliation: Tse FW ( Department of Physiology and Biophysics, University of Washington, Seattle 98195.);
Abstract	Gonadotropin-releasing hormone induces oscillatory release of Ca2+ from inositol trisphosphate-sensitive stores of gonadotropes. Simultaneously with electrophysiological measures of cytoplasmic [Ca2+], corresponding changes in [Ca2+] within intracellular stores were monitored with a fluorescent dye, mag-indo-1. Each cycle of oscillation released only 10% of the detectable stored Ca2+. Some Ca2+ was recovered by the stores using a mechanism sensitive to inhibitors of intracellular Ca2+ ATPases, and much of the remainder was temporarily and rapidly pumped into other intracellular compartments or out of the cell. The dynamics of Ca2+ oscillations are thus more complex than a repeated emptying and refilling of a single compartment. The free concentrations measured show that intracellular Ca2+ store compartments contain strong Ca2+ buffers.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Metabolism Gonadotropin-Releasing Hormone Pharmacology Pituitary Gland, Anterior Animals Calcium-Transporting ATPases Antagonists & Inhibitors Hydroquinones In Vitro Techniques Kinetics Oscillometry Cytology Drug Effects Rats, Sprague-Dawley Terpenes Thapsigargin Time Factors Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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