NDLI: Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.

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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.

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Hypoxia induces voltage-dependent Ca2+ entry and quantal dopamine secretion in carotid body glomus cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Alvarez De Toledo, G. A. Fernández-chacón, R. Benot, A. R. López-barneo, J. Ureña, J.
Description	Author Affiliation: Ureña J ( Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Facultad de Medicina, Spain.);
Abstract	We have investigated the changes of cytosolic [Ca2+] and the secretory activity in single glomus cells dispersed from rabbit carotid bodies during exposure to solutions with variable O2 tension (Po2). In normoxic conditions (Po2 = 145 mmHg; 1 mmHg = 133 Pa), intracellular [Ca2+] was 58 +/- 29 nM, and switching to low Po2 (between 10 and 60 mmHg) led to a reversible increase of [Ca2+] up to 800 nM. The response to hypoxia completely disappeared after removal of external Ca2+ or with the addition of 0.2 mM Cd2+ to the external solution. These same solutions also abolished both the Ca2+ current of the cells and the increase of internal [Ca2+] elicited by high external K+. Elevations of cytosolic [Ca2+] in response to hypoxia or to direct membrane depolarization elicited the release of dopamine, which was detected by amperometric techniques. Dopamine secretion occurred in episodes of spike-like activity that appear to represent the release from single secretory vesicles. From the mean charge of well-resolved secretory events, we estimated the average number of dopamine molecules per vesicle to be approximately 140,000, a value about 15 times smaller than a previous estimate in chromaffin granules of adrenomedullary cells. These results directly demonstrate in a single-cell preparation the secretory response of glomus cells to hypoxia. The data indicate that the enhancement of cellular excitability upon exposure to low Po2 results in Ca2+ entry through voltage-gated channels, which leads to an increase in intracellular [Ca2+] and exocytotic transmitter release.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-11-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Metabolism Carotid Body Physiology Dopamine Animals Cadmium Pharmacology Cadmium Chloride Cell Hypoxia Chemoreceptor Cells Drug Effects Chlorides Cytosol Secretion Fluorescent Dyes Fura-2 Analogs & Derivatives In Vitro Techniques Kinetics Membrane Potentials Nickel Oxygen Partial Pressure Potassium Chloride Rabbits Time Factors Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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