NDLI: Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

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Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

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Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	He, D. M. Reeves, W. Hendrickson, E. A. Lee, S. E. Pulaski, C. R. Boubnov, N. V. Wills, Z. Band, H. Hall, K. T. Benjamin, D. M.
Description	Author Affiliation: Boubnov NV ( Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA 02115.);
Abstract	Two ionizing radiation-sensitive (IRs) and DNA double-strand break (DSB) mutants, sxi-3 and sxi-2, were shown to be severely deficient in a DNA end binding activity, similar to a previously described activity of the Ku autoantigen, correlating with the xrs (XRCC5) mutations. Cell fusions with xrs-6, another IRs, DSB repair-deficient cell line, defined these sxi mutants in the XRCC5 group. sxi-3 cells have low expression levels of the p86Ku mRNA. Introduction of the Ku p86 gene, but not the p70 Ku gene, complemented the IRs, DNA end binding, and variable (diversity) joining [V(D)J] recombination signal and coding junction deficiencies of sxi-3. Thus, the p86 Ku gene product is essential for DSB repair and V(D)J recombination.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	3
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Antigens, Nuclear DNA Helicases DNA Repair DNA-Binding Proteins Physiology Genetic Complementation Test Mutation Nuclear Proteins Recombination, Genetic Genetics Animals CHO Cells Cell Fusion Cell Line Cricetinae DNA Metabolism DNA Damage RNA, Messenger Biosynthesis Radiation Tolerance Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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