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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Brack, A. Behl, C. Sagara, Y. Lesley, R. Dargusch, R. Kimura, H. Schubert, D. |
| Description | Author Affiliation: Schubert D ( Salk Institute for Biological Studies, San Diego, CA 92186-5800.); |
| Abstract | beta-Amyloid protein (A beta) is a member of a small group of proteins that accumulate as amyloid deposits in various tissues. It has recently been demonstrated that the toxicity of A beta toward some neural cells is caused by oxidative damage. Since all of the amyloid diseases are characterized by protein deposited in the antiparallel beta-sheet conformation, it was asked whether there is a common toxic mechanism. It is shown here that the protein components of other human amyloidoses, including amylin, calcitonin, and atrial natriuretic peptide, are all toxic to clonal and primary cells. The toxicity is mediated via a free radical pathway indistinguishable from that of A beta. Experiments with synthetic peptides suggest that it is the amphiphilic nature of the peptides generated by their beta structure rather than their beta structure per se that causes toxicity. These results tend to rule out the alternative that amyloid toxicity is exclusively mediated via specific cell surface receptors. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 92 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1995-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Amyloid Beta-Peptides Toxicity Cell Survival Drug Effects Hydrogen Peroxide Metabolism Peptide Fragments Peptides Pharmacology Amino Acid Sequence Amyloid Chemistry Animals Atrial Natriuretic Factor Brain Neoplasms Calcitonin Cell Line Flow Cytometry Islet Amyloid Polypeptide L-Lactate Dehydrogenase Melitten Molecular Sequence Data NADH, NADPH Oxidoreductases Antagonists & Inhibitors Oligopeptides Onium Compounds Protein Structure, Secondary Structure-Activity Relationship Tumor Cells, Cultured Wasp Venoms P-Methoxy-N-methylphenethylamine Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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