NDLI: Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface.

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Cystic fibrosis epithelial cells have a receptor for pathogenic bacteria on their apical surface.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Al-awqati, Q. Prince, A. Barasch, J. Imundo, L.
Description	Author Affiliation: Imundo L ( Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA.);
Abstract	Chronic colonization and infection of the lung with Pseudomonas aeruginosa is the major cause of morbidity and mortality in cystic fibrosis (CF) patients. We found that polarized CF bronchial and pancreatic epithelia bound P. aeruginosa in a reversible and dose-dependent manner. There was significantly greater binding to CF bronchial and pancreatic cells than to their matched pairs rescued with the wild-type CF transmembrane conductance regulator. Bound P. aeruginosa were easily displaced by unlabeled P. aeruginosa but not by Escherichia coli, an organism that does not cause significant pulmonary disease in CF. In contrast, Staphylococcus aureus, a frequent pathogen in CF, could effectively displace bound P. aeruginosa from its receptor. We found undersialylation of apical proteins and a higher concentration of asialoganglioside 1 (aGM1) in apical membranes of CF compared with rescued epithelia. Incubation of P. aeruginosa with aGM1 reduced its binding, as did treatment of the epithelia with the tetrasaccharide moiety of this ganglioside (Gal beta 1-3GalNAc beta 1-4Gal beta 1-4Glc). Finally, an antibody to aGM1 effectively displaced P. aeruginosa from its binding site and blocked binding of S. aureus to CF cells but not to rescued cells. These results show that the tetrasaccharide of aGM1 is a receptor for P. aeruginosa and S. aureus and that its increased abundance in the apical membrane of CF epithelia makes it a likely contributor to the pathogenesis of bacterial infections in the CF lung.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Bacterial Adhesion Cystic Fibrosis Microbiology G(M1) Ganglioside Physiology Pseudomonas Aeruginosa Drug Effects Binding, Competitive Carbohydrate Sequence Carbohydrates Pharmacology Cell Line Epithelium Lung Methionine Metabolism Molecular Sequence Data Oligosaccharides Chemistry Pancreas Pathogenicity Reference Values Staphylococcus Aureus Sulfur Radioisotopes Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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