NDLI: Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

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Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

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Ca(2+)-inhibitable adenylyl cyclase modulates pulmonary artery endothelial cell cAMP content and barrier function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cooper, D. M. Rodman, D. M. Cornfield, D. N. Mcmurtry, I. F. Stevens, T. Nakahashi, Y.
Description	Author Affiliation: Stevens T ( Department of Anesthesiology, University of Colorado Health Sciences Center, Denver 80262, USA.);
Abstract	Maintenance by the endothelium of a semi-permeable barrier is critically important in the exchange of oxygen and carbon dioxide in the lung. Intracellular free Ca2+ ([Ca2+]i) and cAMP are principal determinants of endothelial cell barrier function through their mutually opposing actions on endothelial retraction. However, details of the mechanisms of this antagonism are lacking. The recent discovery that certain adenylyl cyclases (EC 4.6.1.1) could be acutely inhibited by Ca2+ in the intracellular concentration range provided one possible mechanism whereby elevated [Ca2+]i could decrease cAMP content. This possibility was explored in pulmonary artery endothelial cells. The results indicate that a type VI Ca(2+)-inhibitable adenylyl cyclase exists in pulmonary artery endothelial cells and is modulated by physiological changes in [Ca2+]i. Furthermore, the results suggest the inverse relationship between [Ca2+]i and cAMP that is established by Ca(2+)-inhibitable adenylyl cyclase plays a critical role in modulating pulmonary artery endothelial cell permeability. These data provide evidence that susceptibility to inhibition of adenylyl cyclase by Ca2+ can be exploited in modulating a central physiological process.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adenylate Cyclase Metabolism Calcium Cyclic AMP Endothelium, Vascular Physiology Gene Expression Pulmonary Artery Biosynthesis Isolation & Purification Amino Acid Sequence Animals Bradykinin Pharmacology Cell Membrane Cells, Cultured DNA, Complementary Chemistry Enzymology Fura-2 Ionomycin Lanthanum Manganese Mice Molecular Sequence Data RNA, Messenger Sequence Homology, Amino Acid Spectrometry, Fluorescence Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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