NDLI: Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1995 Volume: 92 Issue: 26

Year: 1995 Volume: 92 Issue: 25

Year: 1995 Volume: 92 Issue: 24

Year: 1995 Volume: 92 Issue: 23

Year: 1995 Volume: 92 Issue: 22

Year: 1995 Volume: 92 Issue: 21

Year: 1995 Volume: 92 Issue: 20

Year: 1995 Volume: 92 Issue: 19

Year: 1995 Volume: 92 Issue: 18

Evolutionary consequences of food chain length in kelp forest communities.

Microevolutionary responses in experimental populations of plants to CO2-enriched environments: parallel results from two model systems.

Is water structure around hydrophobic groups clathrate-like?

De novo biosynthesis of the aggregation pheromone components ipsenol and ipsdienol by the pine bark beetles Ips paraconfusus Lanier and Ips pini (Say) (Coleoptera: Scolytidae).

Amino-terminal alteration of the HLA-A*0201-restricted human immunodeficiency virus pol peptide increases complex stability and in vitro immunogenicity.

Follicular lymphomas can be induced to present alloantigen efficiently: a conceptual model to improve their tumor immunogenicity.

Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors.

Development in one dimension: the rapid differentiation of Dictyostelium discoideum in glass capillaries.

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

Toward the therapeutic editing of mutated RNA sequences.

Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1.

High-level expression of functional rat neuronal nitric oxide synthase in Escherichia coli.

Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity.

Hypertonicity activates nonselective cation channels in mouse cortical collecting duct cells.

The dynamic nature of polyploid genomes.

An evolutionary theory of the family.

Interaction of GroEL with a highly structured folding intermediate: iterative binding cycles do not involve unfolding.

Photodissociation of a (mu-peroxo)(mu-hydroxo)bis[bis(bipyridyl)-cobalt(III)] complex: a tool to study fast biological reactions involving O2.

A variant of lambda repressor with an altered pattern of cooperative binding to DNA sites.

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity.

Thermosensitive phenotype of transgenic mice overproducing human glutathione peroxidases.

Immunophenotyping of melanomas for tyrosinase: implications for vaccine development.

Tissue engineered perivascular endothelial cell implants regulate vascular injury.

Object-related activity revealed by functional magnetic resonance imaging in human occipital cortex.

Forced evolution of glutathione S-transferase to create a more efficient drug detoxication enzyme.

Targeted gene inactivation in petunia by PCR-based selection of transposon insertion mutants.

Tyrosine phosphorylation accompanying the cellularization of the syncytial blastoderm of Drosophila.

Rates of decomposition of ribose and other sugars: implications for chemical evolution.

On the mechanism of the anticlotting action of vitamin E quinone.

The 3'-terminal exon of the family of steroid and phenol sulfotransferase genes is spliced at the N-terminal glycine of the universally conserved GXXGXXK motif that forms the sulfonate donor binding site.

Homeobox-containing gene transiently expressed in a spatially restricted pattern in the early sea urchin embryo.

Cryptorchidism and homeotic transformations of spinal nerves and vertebrae in Hoxa-10 mutant mice.

Coordinate regulation of Bacillus subtilis peroxide stress genes by hydrogen peroxide and metal ions.

Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors.

Tissue factor promotes melanoma metastasis by a pathway independent of blood coagulation.

Localization of visual stimuli after striate cortex damage in monkeys: parallels with human blindsight.

Modeling and optimization of populations subject to time-dependent mutation.

Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.

The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element.

Structural domains of IS10 transposase and reconstitution of transposition activity from proteolytic fragments lacking an interdomain linker.

Determination of the distance between two spin labels attached to a macromolecule.

Single-headed myosin II acts as a dominant negative mutation in Dictyostelium.

Flightless brown kiwis of New Zealand possess extremely subdivided population structure and cryptic species like small mammals.

Predicting coiled coils by use of pairwise residue correlations.

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E.

A general model of invariant chain association with class II major histocompatibility complex proteins.

Retrograde axonal transport of glial cell line-derived neurotrophic factor in the adult nigrostriatal system suggests a trophic role in the adult.

Two types of calcium response limited to single spines in cerebellar Purkinje cells.

Interactions between the retinoid X receptor and a conserved region of the TATA-binding protein mediate hormone-dependent transactivation.

Host factors LR1 and Sp1 regulate the Fp promoter of Epstein-Barr virus.

Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.

Structural features of the invariant chain fragment CLIP controlling rapid release from HLA-DR molecules and inhibition of peptide binding.

Tumor necrosis factor-induced apoptosis is mediated by a CrmA-sensitive cell death pathway.

Specific induction of cAMP in Langerhans cells by calcitonin gene-related peptide: relevance to functional effects.

Rapid endocytosis coupled to exocytosis in adrenal chromaffin cells involves Ca2+, GTP, and dynamin but not clathrin.

Disparate actions of hydroxyurea in potentiation of purine and pyrimidine 2',3'-dideoxynucleoside activities against replication of human immunodeficiency virus.

Antisense DNA downregulation of the ERBB2 oncogene measured by a flow cytometric assay.

The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity.

Increased activity of p53 in senescing fibroblasts.

Human intestinal epithelial cells express functional cytokine receptors sharing the common gamma c chain of the interleukin 2 receptor.

Radiometal labeling of recombinant proteins by a genetically engineered minimal chelation site: technetium-99m coordination by single-chain Fv antibody fusion proteins through a C-terminal cysteinyl peptide.

Three gonadotropin-releasing hormone genes in one organism suggest novel roles for an ancient peptide.

Periodic variation in side-chain polarities of T-cell antigenic peptides correlates with their structure and activity.

p53 expression is required for thymocyte apoptosis induced by adenosine deaminase deficiency.

Leukotriene A4 hydrolase: mapping of a henicosapeptide involved in mechanism-based inactivation.

Efficient recovery of infectious vesicular stomatitis virus entirely from cDNA clones.

Complete sequence of the bithorax complex of Drosophila.

Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila.

Repacking protein cores with backbone freedom: structure prediction for coiled coils.

Close association of the alpha subunits of Gq and G11 G proteins with actin filaments in WRK1 cells: relation to G protein-mediated phospholipase C activation.

Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats.

Expression of an Arabidopsis cryptochrome gene in transgenic tobacco results in hypersensitivity to blue, UV-A, and green light.

The mechanism of action of phenylalanine ammonia-lyase: the role of prosthetic dehydroalanine.

Conformation, energy, and folding ability of selected amino acid sequences.

Isolation and characterization of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: identification of residues important for toxicity.

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells.

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.

Incorporation of reconstituted acetylcholine receptors from Torpedo into the Xenopus oocyte membrane.

Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses.

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts.

Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

Evidence against the exon theory of genes derived from the triose-phosphate isomerase gene.

Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory.

Crossover and noncrossover recombination during meiosis: timing and pathway relationships.

p53 deficiency does not affect the accumulation of point mutations in a transgene target.

Intratumoral injection of an adenovirus expressing interleukin 2 induces regression and immunity in a murine breast cancer model.

Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages.

Year: 1995 Volume: 92 Issue: 17

Year: 1995 Volume: 92 Issue: 16

Year: 1995 Volume: 92 Issue: 15

Year: 1995 Volume: 92 Issue: 14

Year: 1995 Volume: 92 Issue: 13

Year: 1995 Volume: 92 Issue: 12

Year: 1995 Volume: 92 Issue: 11

Year: 1995 Volume: 92 Issue: 10

Year: 1995 Volume: 92 Issue: 9

Year: 1995 Volume: 92 Issue: 8

Year: 1995 Volume: 92 Issue: 7

Year: 1995 Volume: 92 Issue: 6

Year: 1995 Volume: 92 Issue: 5

Year: 1995 Volume: 92 Issue: 4

Year: 1995 Volume: 92 Issue: 3

Year: 1995 Volume: 92 Issue: 2

Year: 1995 Volume: 92 Issue: 1

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

Seven newly discovered intron positions in the triose-phosphate isomerase gene: evidence for the introns-late theory.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dixon, C. D-jafari, J. Walker, V. K. Tyshenko, M. G. Logsdon, J. M. Palmer, J. D.
Description	Author Affiliation: Logsdon JM ( Department of Biology, Indiana University, Bloomington 47405, USA.);
Abstract	The gene encoding the glycolytic enzyme triose-phosphate isomerase (TPI; EC 5.3.1.1) has been central to the long-standing controversy on the origin and evolutionary significance of spliceosomal introns by virtue of its pivotal support for the introns-early view, or exon theory of genes. Putative correlations between intron positions and TPI protein structure have led to the conjecture that the gene was assembled by exon shuffling, and five TPI intron positions are old by the criterion of being conserved between animals and plants. We have sequenced TPI genes from three diverse eukaryotes--the basidiomycete Coprinus cinereus, the nematode Caenorhabditis elegans, and the insect Heliothis virescens--and have found introns at seven novel positions that disrupt previously recognized gene/protein structure correlations. The set of 21 TPI introns now known is consistent with a random model of intron insertion. Twelve of the 21 TPI introns appear to be of recent origin since each is present in but a single examined species. These results, together with their implication that as more TPI genes are sequenced more intron positions will be found, render TPI untenable as a paradigm for the introns-early theory and, instead, support the introns-late view that spliceosomal introns have been inserted into preexisting genes during eukaryotic evolution.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Basidiomycota Genetics Caenorhabditis Elegans Insects Introns Triose-Phosphate Isomerase Amino Acid Sequence Animals Enzymology Exons Molecular Sequence Data Phylogeny Protein Conformation Sequence Homology, Amino Acid Chemistry Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in