NDLI: Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.

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Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.

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Contrasting roles for Myc and Mad proteins in cellular growth and differentiation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pellicer, I. Cordon-cardo, C. Chin, L. Chen, K. Depinho, R. A. Schreiber-agus, N. Dudast, M. Lee, H. W.
Description	Author Affiliation: Chin L ( Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.);
Abstract	The positive effects of Myc on cellular growth and gene expression are antagonized by activities of another member of the Myc superfamily, Mad. Characterization of the mouse homolog of human mad on the structural level revealed that domains shown previously to be required in the human protein for anti-Myc repression, sequence-specific DNA-binding activity, and dimerization with its partner Max are highly conserved. Conservation is also evident on the biological level in that both human and mouse mad can antagonize the ability of c-myc to cooperate with ras in the malignant transformation of cultured cells. An analysis of c-myc and mad gene expression in the developing mouse showed contrasting patterns with respect to tissue distribution and developmental stage. Regional differences in expression were more striking on the cellular level, particularly in the mouse and human gastrointestinal system, wherein c-Myc protein was readily detected in immature proliferating cells at the base of the colonic crypts, while Mad protein distribution was restricted to the postmitotic differentiated cells in the apex of the crypts. An increasing gradient of Mad was also evident in the more differentiated subcorneal layers of the stratified squamous epithelium of the skin. Together, these observations support the view that both downregulation of Myc and accumulation of Mad may be necessary for progression of precursor cells to a growth-arrested, terminally differentiated state.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	92
Language	English
Publisher	National Academy of Sciences
Publisher Date	1995-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Differentiation Physiology Cell Division DNA-Binding Proteins Proto-Oncogene Proteins C-myc Repressor Proteins Animals Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Cell Transformation, Neoplastic Genetics Intestines Metabolism Mice Molecular Sequence Data Skin Species Specificity Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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