NDLI: Angiotensin II type 2 receptor mediates programmed cell death.

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Angiotensin II type 2 receptor mediates programmed cell death.

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Angiotensin II type 2 receptor mediates programmed cell death.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yamada, T. Horiuchi, M. Dzau, V. J.
Description	Author Affiliation: Yamada T ( Falk Cardiovascular Research Center, Stanford University School of Medicine, CA 94305-5246, USA.);
Abstract	The function of the recently discovered angiotensin II type 2 (AT2) receptor remains elusive. This receptor is expressed abundantly in fetus, but scantily in adult tissues except brain, adrenal medulla, and atretic ovary. In this study, we demonstrated that this receptor mediates programmed cell death (apoptosis). We observed this effect in PC12W cells (rat pheochromocytoma cell line) and R3T3 cells (mouse fibroblast cell line), which express abundant AT2 receptor but not AT1 receptor. The cellular mechanism appears to involve the dephosphorylation of mitogen-activated protein kinase (MAP kinase). Vanadate, a protein-tyrosine-phosphatase inhibitor, attenuated the dephosphorylation of MAP kinases by the AT2 receptor and restored the apoptotic changes. Antisense oligonucleotide to MAP kinase phosphatase 1 inhibited the AT2 receptor-mediated MAP kinase dephosphorylation and blocked the AT2 receptor-mediated apoptosis. These results suggest that protein-tyrosine-phosphatase, including MAP kinase phosphatase 1 activated by the AT2 receptor, is involved in apoptosis. We hypothesize that this apoptotic function of the AT2 receptor may play an important role in developmental biology and pathophysiology.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	1
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Apoptosis Cell Cycle Proteins Immediate-Early Proteins Metabolism Phosphoprotein Phosphatases Protein Tyrosine Phosphatases Receptors, Angiotensin Physiology 3T3 Cells Animals Calcium-Calmodulin-Dependent Protein Kinases Dual Specificity Phosphatase 1 Mice Molecular Sequence Data Nerve Growth Factors Pharmacology Oligonucleotides, Antisense Chemistry PC12 Cells Protein Phosphatase 1 Recombinant Proteins Signal Transduction Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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