NDLI: Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

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Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

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Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translation.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bamford, R. N. Sharma, H. Waldmann, T. A. Battiata, A. P. Burton, J. D.
Description	Author Affiliation: Bamford RN ( Metabolism Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1374, USA.);
Abstract	We reported previously that the human T-cell lymphotrophic virus type I (HTLV-I)-associated adult T-cell leukemia line HuT-102 produces a cytokine designated interleukin (IL) T that requires interleukin (IL) 2 receptor beta-subunit expression for its action. Using anti-cytokine antibodies, we demonstrated that IL-T is identical to the simultaneously described IL-15. When compared to activated monocytes, IL-15 mRNA expression was 6- to 10-fold greater in HuT-102 cells. The predominant IL-15 message from HuT-102 is a chimeric mRNA joining a segment of the R region of the long terminal repeat of HTLV-I and the 5'-untranslated region (UTR) of IL-15. Normally, by alternative splicing, this 118-nucleotide R element represents the most 5' region of several HTLV-I transcripts including tax, rex, and env. The introduction of the R element eliminated over 200 nucleotides of the IL-15 5'-UTR, including 8 of 10 upstream AUGs that are present in normal IL-15 messages. On analysis of the 5'-UTR of normal IL-15, we demonstrated that the presence of these 10 upstream AUGs interferes with IL-15 mRNA translation. Thus, IL-15 synthesis by the adult T-cell leukemia line HuT- 102 involves an increase in IL-15 mRNA transcription and translation secondary to the production of an HTLV-I R element fusion message that lacks many upstream AUGs.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Gene Expression Regulation, Viral Human T-lymphotropic Virus 1 Immunology Interleukins Biosynthesis Leukemia-Lymphoma, Adult T-Cell Protein Biosynthesis Recombinant Fusion Proteins T-Lymphocytes Cell Line Codon Genetics Interleukin-15 Lipopolysaccharides Pharmacology Lymphocyte Activation Molecular Sequence Data Monocytes RNA, Messenger Metabolism Drug Effects T-Lymphocytes, Cytotoxic Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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