NDLI: Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

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Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Attaix, D. Boirie, Y. Beaufrere, B. Mansoor, O. Ralliere, C. Arnal, M. Schoeffler, P. Taillandier, D. Aurousseau, E.
Description	Author Affiliation: Mansoor O ( Service de Réanimation, Centre Hospitalo-Universitaire, Clermont- Ferrand, France.);
Abstract	The cellular mechanisms responsible for enhanced muscle protein breakdown in hospitalized patients, which frequently results in lean body wasting, are unknown. To determine whether the lysosomal, Ca2+-activated, and ubiquitin-proteasome proteolytic pathways are activated, we measured mRNA levels for components of these processes in muscle biopsies from severe head trauma patients. These patients exhibited negative nitrogen balance and increased rates of whole-body protein breakdown (assessed by [13C]leucine infusion) and of myofibrillar protein breakdown (assessed by 3-methylhistidine urinary excretion). Increased muscle mRNA levels for cathepsin D, m-calpain, and critical components of the ubiquitin proteolytic pathway (i.e., ubiquitin, the 14-kDa ubiquitin-conjugating enzyme E2, and proteasome subunits) paralleled these metabolic adaptations. The data clearly support a role for multiple proteolytic processes in increased muscle proteolysis. The ubiquitin proteolytic pathway could be activated by altered glucocorticoid production and/or increased circulating levels of interleukin 1beta and interleukin 6 observed in head trauma patients and account for the breakdown of myofibrillar proteins, as was recently reported in animal studies.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Metabolism Craniocerebral Trauma Cysteine Endopeptidases Biosynthesis Gene Expression Lysosomes Enzymology Multienzyme Complexes Muscle, Skeletal RNA, Messenger Ubiquitins Blotting, Northern Blood Immunology Glyceraldehyde-3-Phosphate Dehydrogenases Interleukin-1 Interleukin-6 Proteasome Endopeptidase Complex Reference Values Tumor Necrosis Factor-alpha Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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