NDLI: Hypothesis: 'Rogue cell'-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis.

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Hypothesis: 'Rogue cell'-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis.

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Hypothesis: 'Rogue cell'-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncopenesis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Satoh, C. Glover, T. Traub, R. Curfman, B. Major, E. O. Burgess, A. Awa, A. A. Neel, J. V.
Spatial Coverage	Japan
Description	Author Affiliation: Neel JV ( Department of Human Genetics, University of Michigan Medical School, Ann Arbor, 48109-0618, USA.);
Abstract	The hemagglutination inhibition antibody titers against the JC and BK polyoma viruses (JCV and BKV, respectively) are significantly elevated in individuals exhibiting 'rogue' cells among their cultured lymphocytes. However, the elevation is so much greater with respect to JCV that the BKV elevation could readily be explained by cross reactivity to the capsid protein of these two closely related viruses. The JCV exhibits high sequence homology with the simian papovavirus, simian virus 40 (SV40), and inoculation of human fetal brain cells with JCV produces polyploidy and chromosomal damage very similar to that produced by SV40. We suggest, by analogy with the effects of SV40, that these changes are due to the action of the viral large tumor antigen, a pluripotent DNA binding protein that acts in both transcription and replication. The implications of these findings for oncogenesis are briefly discussed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	7
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-05-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	BK Virus Cell Transformation, Neoplastic Chromosome Aberrations JC Virus Lymphocytes Immunology Papillomavirus Infections Polyploidy Tumor Virus Infections Adolescent Antibodies, Viral Blood Genetics Brain Virology Cells, Cultured Fetus Hemagglutination Inhibition Tests Pathology Nuclear Warfare Reference Values Sequence Homology, Nucleic Acid Simian Virus 40 Transcription, Genetic Comparative Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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