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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhou, N. Yao, T. P. Ku, G. Scully, R. Livingston, D. M. |
| Description | Author Affiliation: Yao TP ( Dana-Farber Cancer Institute, Boston, MA, USA.); |
| Abstract | p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their interaction with the activated forms of certain transcription factors. In a search for additional cellular targets of p300/CBP, a protein-protein cloning strategy, surprisingly identified SRC-1, a coactivator involved in nuclear hormone receptor transcriptional activity, as a p300/CBP interactive protein. p300 and SRC-1 interact, specifically, in vitro and they also form complexes in vivo. Moreover, we show that SRC-1 encodes a new member of the basic helix-loop-helix-PAS domain family and that it physically interacts with the retinoic acid receptor in response to hormone binding. Together, these results implicate p300 as a component of the retinoic acid signaling pathway, operating, in part, through specific interaction with a nuclear hormone receptor coactivator, SRC-1. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 20 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-11-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Nuclear Proteins Metabolism Trans-Activators Transcription Factors Transcription, Genetic Amino Acid Sequence Animals Cell Compartmentation Cloning, Molecular Consensus Sequence DNA, Complementary Genetics E1A-Associated P300 Protein Fluorescent Antibody Technique, Indirect Histone Acetyltransferases Macromolecular Substances Mice Molecular Sequence Data Nuclear Receptor Coactivator 1 Protein Binding Receptors, Retinoic Acid Sequence Alignment Sequence Homology, Amino Acid Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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