NDLI: Nitric oxide production in SJL mice bearing the RcsX lymphoma: a model for in vivo toxicological evaluation of NO.

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Nitric oxide production in SJL mice bearing the RcsX lymphoma: a model for in vivo toxicological evaluation of NO.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tannenbaum, S. R. Gal, A. Tamir, S. Wogan, G. N.
Description	Author Affiliation: Gal A ( Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.);
Abstract	SJL mice spontaneously develop pre-B-cell lymphoma that we hypothesized might stimulate macrophages to produce nitric oxide (NO.). Transplantation of an aggressive lymphoma (RcsX) was used to induce tumor formation. Urinary nitrate excretion was measured as an index of NO. production and was found to increase 50-fold by 13 days after tumor injection. NO. production was prevented by the addition of a nitric oxide synthase (NOS) inhibitor. The expression of inducible NOS (iNOS) in various tissues was estimated by Western blot analysis and localized by immunohistochemistry. The synthase was detected in the spleen, lymph nodes, and liver of treated but not control mice. To assess whether the iNOS-staining cells were macrophages, spleen sections from ResX-bearing animals were costained with anti-iNOS antibody and the anti-macrophage antibody moma-2. Expression of iNOS was found to be limited to a subset of the macrophage population. The concentration of gamma-interferon, a cytokine known to induce NO. production by macrophages, in the serum of tumor-bearing mice, was measured and found to be elevated 25-fold above untreated mice. The ability of ResX-activated macrophages to inhibit splenocyte growth in primary culture was estimated and macrophage-derived NO. was found to inhibit cell division 10-fold. Our findings demonstrate that ResX cells stimulate NO. production by macrophages in the spleen and lymph nodes of SJL mice, and we believe this experimental model will prove useful for study of the toxicological effects of NO. under physiological conditions.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	21
Volume Number	93
Language	English
Publisher	National Academy of Sciences
Publisher Date	1996-12-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Lymphoma Metabolism Macrophages Nitric Oxide Synthase Biosynthesis Nitric Oxide Animals Antigens, Surface Biological Markers Urine Cell Adhesion Cell Division Cells, Cultured Gene Expression Interferon-gamma Blood Isoenzymes Lymph Nodes Enzymology Immunology Pathology Mice Mice, Inbred Strains Neoplasm Transplantation Nitrates Spleen Tumor Cells, Cultured Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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