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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Robertson, E. S. Ooka, T. Kieff, E. D. |
| Description | Author Affiliation: Robertson ES ( Department of Microbiology, Harvard Medical School, Boston, MA 02115, USA.); |
| Abstract | Basic research in Epstein-Barr virus (EBV) molecular genetics has provided means to maintain episomes in human cells, to efficiently deliver episomes with up to 150 kbp of heterologous DNA to human B lymphocytes, and to immortalize human B lymphocytes with EBV recombinants that can maintain up to 120 kbp of heterologous DNA. Episome maintenance requires an EBV nuclear protein, EBNA1, whereas immortalization of cells with EBV recombinants requires EBNA1, EBNA2, EBNA3A, EBNA3C, EBNALP, and LMP1. EBV-derived vectors are useful for experimental genetic reconstitution in B lymphocytes, a cell type frequently used in establishing repositories of human genetic deficiencies. The ability of EBV-infected cells to establish a balanced state of persistence in normal humans raises the possibility that cells infected with EBV recombinants could be useful for genetic reconstitution, in vivo. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 21 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-12-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | B-Lymphocytes Physiology Epstein-Barr Virus Nuclear Antigens Biosynthesis Genetic Vectors Herpesvirus 4, Human Genetics Transfection Virology Burkitt Lymphoma Cell Line Cell Transformation, Viral Cells, Cultured Genetic Markers Genetic Therapy Open Reading Frames Polymerase Chain Reaction Recombinant Proteins Recombination, Genetic Tumor Cells, Cultured Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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