NDLI: Behavioral effects of estrogen receptor gene disruption in male mice.

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Behavioral effects of estrogen receptor gene disruption in male mice.

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Behavioral effects of estrogen receptor gene disruption in male mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ogawa, S. Korach, K. S. Pfaff, D. W. Lubahn, D. B.
Description	Author Affiliation: Ogawa S ( Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, NY 10021, USA.);
Abstract	Gonadal steroid hormones regulate sexually dimorphic development of brain functions and behaviors. Their nuclear receptors offer the opportunity to relate molecular events in neurons to simple instinctive mammalian behaviors. We have determined the role of estrogen receptor (ER) activation by endogenous estrogen in the development of male-typical behaviors by the use of transgenic estrogen-receptor-deficient (ERKO) mice. Surprisingly, in spite of the fact that they are infertile, ERKO mice showed normal motivation to mount females but they achieved less intromissions and virtually no ejaculations. Aggressive behaviors were dramatically reduced and male-typical offensive attacks were rarely displayed by ERKO males. Moreover, ER gene disruption demasculinized open-field behaviors. In the brain, despite the evident loss of functional ER protein, the androgen-dependent system appears to be normally present in ERKO mice. Together, these findings indicate that ER gene expression during development plays a major role in the organization of male-typical aggressive and emotional behaviors in addition to simple sexual behaviors.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Behavior, Animal Physiology Brain Receptors, Estrogen Deficiency Sex Characteristics Aggression Analysis Of Variance Animals Aromatase Isolation & Purification Emotions Exploratory Behavior Immunohistochemistry Mice Mice, Mutant Strains Mice, Transgenic Motor Activity Receptors, Androgen Sexual Behavior, Animal Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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