NDLI: RNA-dependent phosphorylation of a nuclear RNA binding protein.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1997 Volume: 94 Issue: 26

Year: 1997 Volume: 94 Issue: 25

Year: 1997 Volume: 94 Issue: 24

Year: 1997 Volume: 94 Issue: 23

Year: 1997 Volume: 94 Issue: 22

Year: 1997 Volume: 94 Issue: 21

Year: 1997 Volume: 94 Issue: 20

Year: 1997 Volume: 94 Issue: 19

Year: 1997 Volume: 94 Issue: 18

Year: 1997 Volume: 94 Issue: 17

Year: 1997 Volume: 94 Issue: 16

Year: 1997 Volume: 94 Issue: 15

Year: 1997 Volume: 94 Issue: 14

Year: 1997 Volume: 94 Issue: 13

Year: 1997 Volume: 94 Issue: 12

Year: 1997 Volume: 94 Issue: 11

Year: 1997 Volume: 94 Issue: 10

Year: 1997 Volume: 94 Issue: 9

Year: 1997 Volume: 94 Issue: 8

Year: 1997 Volume: 94 Issue: 7

Year: 1997 Volume: 94 Issue: 6

Year: 1997 Volume: 94 Issue: 5

Year: 1997 Volume: 94 Issue: 4

A new approach for containment of microorganisms: dual control of streptavidin expression by antisense RNA and the T7 transcription system.

RNA-dependent phosphorylation of a nuclear RNA binding protein.

Assembly of an active enzyme by the linkage of two protein modules.

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

Native-like structure of a protein-folding intermediate bound to the chaperonin GroEL.

Kinesin-73 in the nervous system of Drosophila embryos.

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I.

Catalysis of protein folding by symmetric chaperone complexes.

Characterization of two scleroderma autoimmune antigens that copurify with human ribonuclease P.

The effect of macromolecular crowding on chaperonin-mediated protein folding.

A novel 3'-end repair mechanism in an RNA virus.

Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control.

Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase

Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster.

Isoform-specific interactions of Na,K-ATPase subunits are mediated via extracellular domains and carbohydrates.

Identification of an animal omega-3 fatty acid desaturase by heterologous expression in Arabidopsis.

Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer

Cryptic single-stranded-DNA binding activities of the phage lambda P and Escherichia coli DnaC replication initiation proteins facilitate the transfer of E. coli DnaB helicase onto DNA.

Novel pyridinium surfactants for efficient, nontoxic in vitro gene delivery.

In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells

Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis.

A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter.

Nucleosome packaging and nucleosome positioning of genomic DNA.

Cloning and sequence analysis of a Bothrops jararaca cDNA encoding a precursor of seven bradykinin-potentiating peptides and a C-type natriuretic peptide.

An endogenous calcium oscillator may control early embryonic division.

Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets.

The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function.

The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation

A system for mutation measurement in mammalian cells: application to gamma-irradiation.

Microtubule-mediated transport of organelles and localization of beta-catenin to the future dorsal side of Xenopus eggs.

Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype.

Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families.

Solar UVB-induced DNA damage and photoenzymatic DNA repair in antarctic zooplankton.

Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts.

Evidence that eukaryotic triosephosphate isomerase is of alpha-proteobacterial origin.

The complete mitochondrial genome of the wallaroo (Macropus robustus) and the phylogenetic relationship among Monotremata, Marsupialia, and Eutheria.

The strength of indirect selection on female mating preferences.

Adenovirus-mediated gene transfer and expression of human beta-glucuronidase gene in the liver, spleen, and central nervous system in mucopolysaccharidosis type VII mice.

Mutations in the mariner transposase: the D,D(35)E consensus sequence is nonfunctional.

Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behçet disease.

High-resolution functional mapping of a cloned gene by genetic footprinting.

Germ-line knockout heterokaryons of an essential alpha-tubulin gene enable high-frequency gene replacement and a test of gene transfer from somatic to germ-line nuclei in Tetrahymena thermophila.

Transcriptional regulation in Archaea: in vivo demonstration of a repressor binding site in a methanogen.

A genetic system to identify DNA polymerase beta mutator mutants.

Evidence for a role for DNA polymerase beta in mammalian meiosis.

An unusual histone H3 specific for early macronuclear development in Euplotes crassus.

Antigen therapy eliminates T cell inflammation by apoptosis: Effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2

Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma.

Allergic airway sensitization induces T cell activation but not airway hyperresponsiveness in B cell-deficient mice.

Identification of the B cell superantigen-binding site of HIV-1 gp120.

Highly purified CD25- resting T cells cannot be infected de novo with HIV-1.

Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function.

Shuttling of initiating kinase between discrete aggregates of the high affinity receptor for IgE regulates the cellular response.

In vivo accumulation of the same anti-melanoma T cell clone in two different metastatic sites.

A complex major histocompatibility complex D locus variant generated by an unusual recombination mechanism in mice.

CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2.

Clade B-based HIV-1 vaccines elicit cross-clade cytotoxic T lymphocyte reactivities in uninfected volunteers.

Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin.

Developmental analysis and subcellular localization of the murine homologue of ELL.

Recombinational construction in Escherichia coli of infectious adenoviral genomes.

Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone.

Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors.

Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow.

Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.

Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor.

The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.

A bacterial basic region leucine zipper histidine kinase regulating toluene degradation.

BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels

A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord.

Suckling and sucrose ingestion suppress persistent hyperalgesia and spinal Fos expression after forepaw inflammation in infant rats.

Behavioral effects of estrogen receptor gene disruption in male mice.

Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein.

Ataxia and altered dendritic calcium signaling in mice carrying a targeted null mutation of the calbindin D28k gene.

A post-tetanic time window for the reinforcement of long-term potentiation by appetitive and aversive stimuli.

Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.

Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry

Molecular determinants of inactivation and G protein modulation in the intracellular loop connecting domains I and II of the calcium channel $α_{1A} subunit$

Relative numbers of cortical and brainstem inputs to the lateral geniculate nucleus.

Brain-derived neurotrophic factor regulates expression of androgen receptors in perineal motoneurons.

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

Pleiotropic effects of a disrupted $K^{+}$ channel gene: Reduced body weight, impaired motor skill and muscle contraction, but no seizures

Co-expression of the neuronal alpha7 and L247T alpha7 mutant subunits yields hybrid nicotinic receptors with properties of both wild-type alpha7 and alpha7 mutant homomeric receptors.

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia.

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease.

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

Characterization of the permeability barrier of human skin in vivo.

Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel

Dependence of intracellular signaling and neurosecretion on phospholipase D activation in immortalized gonadotropin-releasing hormone neurons

Why do mitochondria synthesize fatty acids? Evidence for involvement in lipoic acid production.

Year: 1997 Volume: 94 Issue: 3

Year: 1997 Volume: 94 Issue: 2

Year: 1997 Volume: 94 Issue: 1

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

RNA-dependent phosphorylation of a nuclear RNA binding protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pederson, T. Fung, P. A. Labrecque, R.
Description	Author Affiliation: Fung PA ( Cell Biology Group, Worcester Foundation for Biomedical Research, Shrewsbury, MA 01545, USA.);
Abstract	The human C1 heterogeneous nuclear ribonucleoprotein particle protein (hnRNP protein) undergoes a cycle of phosphorylation-dephosphorylation in HeLa cell nuclear extracts that modulates the binding of this protein to pre-mRNA. We now report that hyperphosphorylation of the C1 hnRNP protein is mediated by a kinase activity in nuclear extracts that is RNA-dependent. Although the basal phosphorylation of the C1 hnRNP protein in nuclear extracts reflects a casein kinase II-type activity, its RNA-dependent hyperphosphorylation appears to be mediated by a different kinase. This is indicated by the unresponsiveness of the RNA-stimulated hyperphosphorylation to casein kinase II inhibitors, and the distinct glycerol gradient sedimentation profiles of the basal versus RNA-stimulated C1 hnRNP protein phosphorylation activities from nuclear extracts. RNA-dependent phosphorylation was observed both for a histidine-tagged recombinant human C1 hnRNP protein added to nuclear extracts and also for the endogenous C1 hnRNP protein. Additional results rule out protein kinase A, protein kinase C, calmodulin-dependent protein kinase II, and double-stranded RNA-activated protein kinase as the enzymes responsible for the RNA-dependent hyperphosphorylation of the C1 hnRNP protein. These results reveal the existence in nuclear extracts of an RNA-dependent protein kinase activity that hyperphosphorylates a known pre-mRNA binding protein, and define an additional element to be integrated into the current picture of how nuclear proteins are regulated by phosphorylation.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	4
Volume Number	94
Language	English
Publisher	National Academy of Sciences
Publisher Date	1997-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Heterogeneous-Nuclear Ribonucleoprotein Group C Nuclear Proteins Metabolism Protein Kinases RNA, Nuclear RNA-Binding Proteins Ribonucleoproteins Casein Kinase II Cell Nucleus Enzyme Inhibitors Pharmacology HeLa Cells Heterogeneous-Nuclear Ribonucleoproteins Models, Biological Phosphorylation Protein-Serine-Threonine Kinases Antagonists & Inhibitors Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in