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Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein.

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Specific interaction of HTLV tax protein and a human type IV neuronal intermediate filament protein.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Liem, R. K. Reddy, T. R. Jones, Y. Li, X. Wong-staal, F. Ellisman, M. H. Ching, G. Y.
Description	Author Affiliation: Reddy TR ( Department of Medicine, University of California at San Diego, La Jolla 92093-0665, USA.);
Abstract	The human T-cell leukemia virus (HTLV) is associated with adult T cell leukemia and neurological disorders (TSP/HAM). The HTLV transcriptional transactivator, Tax, is known to exert its effect through protein-protein interaction with several transcription factors that activate genes in T cell proliferation. The pathogenic mechanism in the CNS is less defined. Using the yeast two-hybrid system, we have identified a specific Tax-binding protein as the neuronal specific intermediate filament protein, alpha-internexin. Tax binds to the domain corresponding to the rod region of alpha-internexin, which is essential for neurofilament assembly. The Tax domains involved in binding are separable from those involved in transactivation. TxBP-1/alpha-internexin and Tax are expressed in the cytoplasm and nucleus, respectively, when expressed alone, but in coexpressing cells, colocalization of both proteins was observed in a perinuclear, punctate distribution. This in vivo interaction also resulted in a dramatic reduction in Tax transactivation and the network formation by alpha-internexin. The specific interaction of Tax and a neuronal specific intermediate filament protein may provide a clue to the pathogenesis of TSP/HAM.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	2
Volume Number	95
Language	English
Publisher	National Academy of Sciences
Publisher Date	1998-02-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Carrier Proteins Metabolism Gene Products, Tax Human T-lymphotropic Virus 1 Amino Acid Sequence Genetics Intermediate Filament Proteins Molecular Sequence Data Nerve Tissue Proteins Protein Binding Sequence Alignment Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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