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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Nielsen, O. Christensen, P. U. Bentley, N. J. Martinho, R. G. Carr, A. M. |
| Description | Author Affiliation: Christensen PU ( Medical Research Council Cell Mutation Unit, Sussex University, Falmer, Sussex, BN1 9RR, United Kingdom.); |
| Abstract | Two paradigms exist for maintaining order during cell-cycle progression: intrinsic controls, where passage through one part of the cell cycle directly affects the ability to execute another, and checkpoint controls, where external pathways impose order in response to aberrant structures. By studying the mitotic inhibitor Mik1, we have identified evidence for an intrinsic link between unperturbed S phase and mitosis. We propose a model in which S/M linkage can be generated by the production and stabilization of Mik1 protein during S phase. The production of Mik1 during unperturbed S phase is independent of the Rad3- and Cds1-dependent checkpoint controls. In response to perturbed S phase, Rad3-Cds1 checkpoint controls are required to maintain high levels of Mik1, probably indirectly by extending the S phase period, where Mik1 is stable. In addition, we find that Mik1 protein can be moderately induced in response to irradiation of G(2) cells in a Chk1-dependent manner. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Mitosis Protein-Tyrosine Kinases Metabolism S Phase Schizosaccharomyces Pombe Proteins Enzyme Inhibitors Pharmacology Epitopes Flow Cytometry G2 Phase Hydroxyurea Immunoblotting Microscopy, Fluorescence Models, Biological Phosphoric Monoester Hydrolases Phosphorylation Protein Kinases Schizosaccharomyces Enzymology Time Factors Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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