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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Xu, Q. Krajewski, S. Reed, J. C. Krajewska, M. Xie, Z. Pawlowski, K. Zhang, H. Godzik, A. Kitada, S. Fuess, S. |
| Description | Author Affiliation: Zhang H ( Program on Apoptosis and Cell Death Regulation, The Burnham Institute, La Jolla, CA 92037, USA.); |
| Abstract | Two major pathways for induction of apoptosis have been identified-intrinsic and extrinsic. The extrinsic pathway is represented by tumor necrosis factor family receptors, which utilize protein interaction modules known as death domains and death effector domains (DEDs) to assemble receptor signaling complexes that recruit and activate certain caspase-family cell death proteases, namely procaspases-8 and -10. The intrinsic pathway for apoptosis involves the participation of mitochondria, which release caspase-activating proteins. Bcl-2 family proteins govern this mitochondria-dependent apoptosis pathway, with proteins such as Bax functioning as inducers and proteins such as Bcl-2 and Bcl-X(L) serving as suppressors of cell death. An apoptosis regulator, BAR, was identified by using a yeast-based screen for inhibitors of Bax-induced cell death. The BAR protein contains a SAM domain, which is required for its interactions with Bcl-2 and Bcl-X(L) and for suppression of Bax-induced cell death in both mammalian cells and yeast. In addition, BAR contains a DED-like domain responsible for its interaction with DED-containing procaspases and suppression of Fas-induced apoptosis. Furthermore, BAR can bridge procaspase-8 and Bcl-2 into a protein complex. The BAR protein is anchored in intracellular membranes where Bcl-2 resides. BAR therefore may represent a scaffold protein capable of bridging two major apoptosis pathways. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 6 |
| Volume Number | 97 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2000-04-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Adaptor Proteins, Signal Transducing Apoptosis Carrier Proteins Physiology Caspases Membrane Proteins Proto-Oncogene Proteins C-bcl-2 Amino Acid Sequence Antigens, CD95 Metabolism Apoptosis Regulatory Proteins Chemistry Caspase 8 Caspase 9 Cell Line Cloning, Molecular DNA, Complementary Enzyme Precursors Immunohistochemistry Molecular Sequence Data Plasmids Precipitin Tests Protein Structure, Tertiary Proto-Oncogene Proteins Sequence Homology, Amino Acid Time Factors Two-Hybrid System Techniques Bcl-2-Associated X Protein Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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