NDLI: A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 2000 Volume: 97 Issue: 26

Year: 2000 Volume: 97 Issue: 25

Year: 2000 Volume: 97 Issue: 24

Year: 2000 Volume: 97 Issue: 23

Year: 2000 Volume: 97 Issue: 22

Year: 2000 Volume: 97 Issue: 21

Year: 2000 Volume: 97 Issue: 20

Year: 2000 Volume: 97 Issue: 19

Year: 2000 Volume: 97 Issue: 18

Year: 2000 Volume: 97 Issue: 17

Year: 2000 Volume: 97 Issue: 16

Year: 2000 Volume: 97 Issue: 15

Year: 2000 Volume: 97 Issue: 14

Year: 2000 Volume: 97 Issue: 13

Year: 2000 Volume: 97 Issue: 12

Jewish and Middle Eastern non-Jewish populations share a common pool of Y-chromosome biallelic haplotypes.

Transforming growth factor beta -inducible independent binding of SMAD to the Smad7 promoter.

Conserved and divergent aspects of terminal patterning in the beetle Tribolium castaneum.

Regulation of the actin cycle in vivo by actin filament severing.

Simultaneous activation of NADPH oxidase-related proton and electron currents in human neutrophils

Selection-mutation balance in polysomic tetraploids: impact of double reduction and gametophytic selection on the frequency and subchromosomal localization of deleterious mutations.

The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription.

Unfolding proteins by external forces and temperature: the importance of topology and energetics.

Phosphoinositide-3 kinase binds to a proline-rich motif in the Na+, K+-ATPase alpha subunit and regulates its trafficking.

Dynamic actin filaments are required for stable long-term potentiation (LTP) in area CA1 of the hippocampus.

Characterization of the 1918 “Spanish” influenza virus neuraminidase gene

CpG methylation as a mechanism for the regulation of E2F activity.

The Bloom's syndrome gene product promotes branch migration of holliday junctions.

Control of protein crystal nucleation around the metastable liquid-liquid phase boundary.

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.

A potent dimeric peptide antagonist of interleukin-5 that binds two interleukin-5 receptor alpha chains.

Combined effects of radiotherapy and angiostatin gene therapy in glioma tumor model.

Subjective surfaces: a method for completing missing boundaries.

A mechanistic basis for Mre11-directed DNA joining at microhomologies.

Decoupled evolution of coding region and mRNA expression patterns after gene duplication: implications for the neutralist-selectionist debate.

Operons in Escherichia coli: genomic analyses and predictions.

Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways.

The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations.

Ectopic scute induces Drosophila ommatidia development without R8 founder photoreceptors.

Shear stress-induced apoptosis of adherent neutrophils: a mechanism for persistence of cardiovascular device infections.

Modeling RNA folding paths with pseudoknots: application to hepatitis delta virus ribozyme.

Mutations in the molybdenum cofactor biosynthetic protein Cnx1G from Arabidopsis thaliana define functions for molybdopterin binding, molybdenum insertion, and molybdenum cofactor stabilization.

Genome evolution of wild barley (Hordeum spontaneum) by BARE-1 retrotransposon dynamics in response to sharp microclimatic divergence.

Atomic force microscopy reveals the mechanical design of a modular protein.

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

Structural basis for the interaction of the fluorescence probe 8-anilino-1-naphthalene sulfonate (ANS) with the antibiotic target MurA.

Assessment of mitochondrial energy coupling in vivo by 13C/31P NMR.

Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates.

Identification of the human cytochrome P450, P450RAI-2, which is predominantly expressed in the adult cerebellum and is responsible for all-trans-retinoic acid metabolism.

A fusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge.

Long-term impacts of the Exxon Valdez oil spill on sea otters, assessed through age-dependent mortality patterns.

The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.

A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein.

The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative $Na^{+}/H^{+}$ antiporter

Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system.

Unpaired terminal nucleotides and 5' monophosphorylation govern 3' polyadenylation by Escherichia coli poly(A) polymerase I.

Down-regulation of iron regulatory protein 1 gene expression by nitric oxide

The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation

Ordered intracellular RecA-DNA assemblies: a potential site of in vivo RecA-mediated activities.

Identification of a PDZ-domain-containing protein that interacts with the scavenger receptor class B type I.

Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy.

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy.

Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway.

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein.

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein.

The complete optical spectrum of liquid water measured by inelastic x-ray scattering.

Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants.

Prothrombotic phenotype of protein Z deficiency.

The SOS response regulates adaptive mutation.

The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

Severe deficiencies in dopamine signaling in presymptomatic Huntington's disease mice.

Copy-choice recombination by reverse transcriptases: reshuffling of genetic markers mediated by RNA chaperones.

Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe.

The persistence of alien genomes.

Glioblastoma multiforme: the terminator.

A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away.

LINE-1 elements and X chromosome inactivation: a function for 'junk' DNA?

Retrotransposon-mediated genome evolution on a local ecological scale.

Optimal prediction of stiff oscillatory mechanics.

Temperature profiles and bathymetry of some high mountain lakes.

Synthetic receptors as models for alkali metal cation-π binding sites in proteins

Atomic force microscopy captures quantized plastic deformation in gold nanowires.

Enhanced metabolism of halogenated hydrocarbons in transgenic plants containing mammalian cytochrome P450 2E1.

Rational design of nascent metalloenzymes.

Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins.

Crystal structure of RPB5, a universal eukaryotic RNA polymerase subunit and transcription factor interaction target.

Solution structure of the RNA polymerase subunit RPB5 from Methanobacterium thermoautotrophicum.

Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum.

Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARgamma.

Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.

Analysis of mutations and suppressors affecting interactions between the subunits of the HIV type 1 reverse transcriptase.

Nutrient regulation of gene expression by the sterol regulatory element binding proteins: increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo.

Molecular modeling and in vitro activity of an HIV-1-encoded glutathione peroxidase.

Catalytic role of enzymes: short strong H-bond-induced partial proton shuttles and charge redistributions.

Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors.

Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1.

Expression of a nonmyristylated variant of the catalytic subunit of protein kinase A during male germ-cell development.

The preaggregated state of an amyloidogenic protein: hydrostatic pressure converts native transthyretin into the amyloidogenic state.

Biosynthesis of terpenoids: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase of Arabidopsis thaliana.

Identification of the single-strand telomeric DNA binding domain of the Saccharomyces cerevisiae Cdc13 protein.

Thiol-disulfide exchange is involved in the catalytic mechanism of peptide methionine sulfoxide reductase.

Cockroach diuretic hormones: characterization of a calcitonin-like peptide in insects.

Investigation of routes and funnels in protein folding by free energy functional methods.

Mobilization of stem/progenitor cells by sulfated polysaccharides does not require selectin presence.

Defense by foot adhesion in a beetle (Hemisphaerota cyanea).

Olenid trilobites: the oldest known chemoautotrophic symbionts?

Convergent adaptive radiations in Madagascan and Asian ranid frogs reveal covariation between larval and adult traits.

Adaptive variation in lactate dehydrogenase-B gene expression: role of a stress-responsive regulatory element.

Identification of phylogenetic footprints in primate tumor necrosis factor-alpha promoters.

Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.

Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: the Lyon repeat hypothesis.

A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.

Genetic reconstitution of systemic lupus erythematosus immunopathology with polycongenic murine strains.

A critical role for eotaxin in experimental oral antigen-induced eosinophilic gastrointestinal allergy.

Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly?

Trans-splicing vectors expand the utility of adeno-associated virus for gene therapy.

Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia.

Extensive neurite outgrowth and active synapse formation on self-assembling peptide scaffolds.

Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D.

Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation.

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743

In vitro correlates of HIV-2-mediated HIV-1 protection.

Intergeneric poliovirus recombinants for the treatment of malignant glioma.

Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis.

Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice.

Auditory processing parallels reading abilities in adults.

Kainate receptor-mediated synaptic currents in cerebellar Golgi cells are not shaped by diffusion of glutamate.

Mouse numb is an essential gene involved in cortical neurogenesis.

A unique virus complex causes Ageratum yellow vein disease.

Anaerobic chlorophyll isocyclic ring formation in Rhodobacter capsulatus requires a cobalamin cofactor.

Changes in period mRNA levels in the brain and division of labor in honey bee colonies.

Year: 2000 Volume: 97 Issue: 11

Year: 2000 Volume: 97 Issue: 10

Year: 2000 Volume: 97 Issue: 9

Year: 2000 Volume: 97 Issue: 8

Year: 2000 Volume: 97 Issue: 7

Year: 2000 Volume: 97 Issue: 6

Year: 2000 Volume: 97 Issue: 5

Year: 2000 Volume: 97 Issue: 4

Year: 2000 Volume: 97 Issue: 3

Year: 2000 Volume: 97 Issue: 2

Year: 2000 Volume: 97 Issue: 1

Year: 1999 Volume: 96

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wu, H. Willis, F. Fruman, D. Humphries, R. K. Satterthwaite, A. B. Lesche, R. Kanchanastit, P. Witte, O. N. Simon, M. Tarakhovsky, A. Lowell, C. A. Leitges, M. Cantley, L. C. Helgason, C. D. Tedder, T. F.
Description	Author Affiliation: Satterthwaite AB ( Department of Microbiology, Immunology, and Molecular Genetics, and Howard Hughes Medical Institute, University of California, Los Angeles, CA 90095, USA.);
Abstract	Modifier screens have been powerful genetic tools to define signaling pathways in lower organisms. The identification of modifier loci in mice has begun to allow a similar dissection of mammalian signaling pathways. Transgenic mice (Btk(lo)) expressing 25% of endogenous levels of Bruton's tyrosine kinase (Btk) have B cell functional responses between those of wild-type and Btk(-/-) mice. We asked whether reduced dosage or complete deficiency of genes previously implicated as Btk regulators would modify the Btk(lo) phenotype. We used two independent assays of Btk-dependent B cell function. Proliferative response to B cell antigen receptor cross-linking in vitro was chosen as an example of a relatively simple, well-defined signaling system. In vivo response to type II T-independent antigens (TI-II) measures complex interactions among multiple cell types over time and may identify additional Btk pathways. All modifiers identified differentially affected these two assays, indicating that Btk mediates these processes via distinct mechanisms. Loss of Lyn, PTEN (phosphatase and tensin homolog), or SH2-containing inositol phosphatase suppressed the Btk(lo) phenotype in vitro but not in vivo, whereas CD19 and the p85alpha form of phosphoinositide 3-kinase behaved as Btk(lo) enhancers in vivo but not in vitro. Effects of Lyn, PTEN, or p85alpha haploinsufficiency were observed. Haploinsufficiency or complete deficiency of protein kinase C beta, Fyn, CD22, Galphaq, or Galpha11 had no detectable effect on the function of Btk(lo) B cells. A transgenic system creating a reduction in dosage of Btk can therefore be used to identify modifier loci that affect B cell responses and quantitatively rank their contribution to Btk-mediated processes.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	12
Volume Number	97
Language	English
Publisher	National Academy of Sciences
Publisher Date	2000-07-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	B-Lymphocytes Physiology Protein-Tyrosine Kinases Signal Transduction Tumor Suppressor Proteins Animals Antigens, CD19 Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic PTEN Phosphohydrolase Phosphatidylinositol 3-Kinases Phosphoric Monoester Hydrolases Protein Kinase C Receptors, Antigen, B-Cell Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in